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STRINGSTRING
PICK1 PICK1 CAMK2A CAMK2A SH3GL1 SH3GL1 NEDD4 NEDD4 NOG NOG SLC6A3 SLC6A3 SNCA SNCA DRD4 DRD4 TH TH DRD2 DRD2 SLC18A2 SLC18A2
"SLC6A3" - solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (620 aa)    
Predicted Functional Partners:
SNCA
synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation (140 aa)
        score_image score_image score_image   0.999
DRD2
dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) (443 aa)
        score_image score_image score_image   0.984
DRD4
dopamine receptor D4 (419 aa)
        score_image   score_image   0.972
PICK1
protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel (415 aa)
        score_image   score_image   0.959
CAMK2A
calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) (489 aa)
        score_image score_image score_image   0.912
TH
tyrosine hydroxylase; Plays an important role in the physiology of adrenergic neurons (528 aa)
            score_image   0.884
SLC18A2
solute carrier family 18 (vesicular monoamine), member 2; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis (514 aa)
        score_image   score_image   0.854
NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (1247 aa)
        score_image   score_image   0.840
NOG
noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (232 aa)
            score_image   0.823
SH3GL1
SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity) (368 aa)
            score_image   0.823
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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