node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAMK2A | PICK1 | ENSP00000381412 | ENSP00000349465 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel | 0.423 |
CAMK2A | SLC6A3 | ENSP00000381412 | ENSP00000270349 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.912 |
DRD2 | DRD4 | ENSP00000354859 | ENSP00000176183 | dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) | dopamine receptor D4 | 0.912 |
DRD2 | SLC18A2 | ENSP00000354859 | ENSP00000298472 | dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) | solute carrier family 18 (vesicular monoamine), member 2; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis | 0.575 |
DRD2 | SLC6A3 | ENSP00000354859 | ENSP00000270349 | dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.984 |
DRD2 | TH | ENSP00000354859 | ENSP00000370571 | dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) | tyrosine hydroxylase; Plays an important role in the physiology of adrenergic neurons | 0.658 |
DRD4 | DRD2 | ENSP00000176183 | ENSP00000354859 | dopamine receptor D4 | dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) | 0.912 |
DRD4 | SLC18A2 | ENSP00000176183 | ENSP00000298472 | dopamine receptor D4 | solute carrier family 18 (vesicular monoamine), member 2; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis | 0.401 |
DRD4 | SLC6A3 | ENSP00000176183 | ENSP00000270349 | dopamine receptor D4 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.972 |
DRD4 | TH | ENSP00000176183 | ENSP00000370571 | dopamine receptor D4 | tyrosine hydroxylase; Plays an important role in the physiology of adrenergic neurons | 0.580 |
NEDD4 | SLC6A3 | ENSP00000345530 | ENSP00000270349 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.840 |
NEDD4 | SNCA | ENSP00000345530 | ENSP00000338345 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.824 |
NOG | SH3GL1 | ENSP00000328181 | ENSP00000269886 | noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite | SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity) | 0.777 |
NOG | SLC6A3 | ENSP00000328181 | ENSP00000270349 | noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.823 |
PICK1 | CAMK2A | ENSP00000349465 | ENSP00000381412 | protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | 0.423 |
PICK1 | SLC6A3 | ENSP00000349465 | ENSP00000270349 | protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.959 |
SH3GL1 | NOG | ENSP00000269886 | ENSP00000328181 | SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity) | noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite | 0.777 |
SH3GL1 | SLC6A3 | ENSP00000269886 | ENSP00000270349 | SH3-domain GRB2-like 1; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity) | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals | 0.823 |
SLC18A2 | DRD2 | ENSP00000298472 | ENSP00000354859 | solute carrier family 18 (vesicular monoamine), member 2; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis | dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) | 0.575 |
SLC18A2 | DRD4 | ENSP00000298472 | ENSP00000176183 | solute carrier family 18 (vesicular monoamine), member 2; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis | dopamine receptor D4 | 0.401 |