node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAPN13 | PTPN23 | ENSP00000295055 | ENSP00000265562 | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.699 |
CAPN13 | ZNF581 | ENSP00000295055 | ENSP00000270451 | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | zinc finger protein 581; May be involved in transcriptional regulation | 0.430 |
DAZAP2 | RBPMS | ENSP00000448051 | ENSP00000340176 | DAZ associated protein 2 | RNA binding protein with multiple splicing; Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA | 0.659 |
DAZAP2 | ZNF581 | ENSP00000448051 | ENSP00000270451 | DAZ associated protein 2 | zinc finger protein 581; May be involved in transcriptional regulation | 0.459 |
FBXL19 | ZNF581 | ENSP00000369666 | ENSP00000270451 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 581; May be involved in transcriptional regulation | 0.501 |
KDM2A | ZNF581 | ENSP00000432786 | ENSP00000270451 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 581; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF581 | ENSP00000366271 | ENSP00000270451 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 581; May be involved in transcriptional regulation | 0.501 |
PLSCR1 | ZNF581 | ENSP00000345494 | ENSP00000270451 | phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | zinc finger protein 581; May be involved in transcriptional regulation | 0.578 |
PTPN23 | CAPN13 | ENSP00000265562 | ENSP00000295055 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | 0.699 |
PTPN23 | ZNF581 | ENSP00000265562 | ENSP00000270451 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 581; May be involved in transcriptional regulation | 0.476 |
RANBP2 | ZNF581 | ENSP00000283195 | ENSP00000270451 | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | zinc finger protein 581; May be involved in transcriptional regulation | 0.465 |
RBPMS | DAZAP2 | ENSP00000340176 | ENSP00000448051 | RNA binding protein with multiple splicing; Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA | DAZ associated protein 2 | 0.659 |
RBPMS | ZNF581 | ENSP00000340176 | ENSP00000270451 | RNA binding protein with multiple splicing; Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA | zinc finger protein 581; May be involved in transcriptional regulation | 0.555 |
XRN1 | ZNF581 | ENSP00000264951 | ENSP00000270451 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 581; May be involved in transcriptional regulation | 0.543 |
ZNF581 | CAPN13 | ENSP00000270451 | ENSP00000295055 | zinc finger protein 581; May be involved in transcriptional regulation | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | 0.430 |
ZNF581 | DAZAP2 | ENSP00000270451 | ENSP00000448051 | zinc finger protein 581; May be involved in transcriptional regulation | DAZ associated protein 2 | 0.459 |
ZNF581 | FBXL19 | ENSP00000270451 | ENSP00000369666 | zinc finger protein 581; May be involved in transcriptional regulation | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
ZNF581 | KDM2A | ENSP00000270451 | ENSP00000432786 | zinc finger protein 581; May be involved in transcriptional regulation | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
ZNF581 | KDM2B | ENSP00000270451 | ENSP00000366271 | zinc finger protein 581; May be involved in transcriptional regulation | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.501 |
ZNF581 | PLSCR1 | ENSP00000270451 | ENSP00000345494 | zinc finger protein 581; May be involved in transcriptional regulation | phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system | 0.578 |