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CCDC164 CCDC164 DNAAF3 DNAAF3 CCDC40 CCDC40 CCDC114 CCDC114 HEATR2 HEATR2 RSPH4A RSPH4A CCDC39 CCDC39 RSPH1 RSPH1 C19orf52 C19orf52 CCDC65 CCDC65 UBC UBC
"C19orf52" - chromosome 19 open reading frame 52 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C19orf52chromosome 19 open reading frame 52 (260 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.721
CCDC164
coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending (740 aa)
            score_image   0.700
CCDC114
coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) (670 aa)
            score_image   0.660
CCDC65
coiled-coil domain containing 65 (484 aa)
            score_image   0.648
CCDC40
coiled-coil domain containing 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 (1142 aa)
            score_image   0.583
DNAAF3
dynein, axonemal, assembly factor 3; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (588 aa)
            score_image   0.583
RSPH4A
radial spoke head 4 homolog A (Chlamydomonas); Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules (716 aa)
            score_image   0.570
CCDC39
coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly (941 aa)
            score_image   0.564
HEATR2
HEAT repeat containing 2 (855 aa)
            score_image   0.510
RSPH1
radial spoke head 1 homolog (Chlamydomonas); May play an important role in male meiosis (By similarity) (309 aa)
            score_image   0.506
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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