node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C19orf52 | CCDC114 | ENSP00000270502 | ENSP00000318429 | chromosome 19 open reading frame 52 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) | 0.660 |
C19orf52 | CCDC164 | ENSP00000270502 | ENSP00000288710 | chromosome 19 open reading frame 52 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | 0.700 |
C19orf52 | CCDC39 | ENSP00000270502 | ENSP00000405708 | chromosome 19 open reading frame 52 | coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly | 0.564 |
C19orf52 | CCDC40 | ENSP00000270502 | ENSP00000380679 | chromosome 19 open reading frame 52 | coiled-coil domain containing 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 | 0.583 |
C19orf52 | CCDC65 | ENSP00000270502 | ENSP00000312706 | chromosome 19 open reading frame 52 | coiled-coil domain containing 65 | 0.648 |
C19orf52 | DNAAF3 | ENSP00000270502 | ENSP00000375599 | chromosome 19 open reading frame 52 | dynein, axonemal, assembly factor 3; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia | 0.583 |
C19orf52 | HEATR2 | ENSP00000270502 | ENSP00000297440 | chromosome 19 open reading frame 52 | HEAT repeat containing 2 | 0.510 |
C19orf52 | RSPH1 | ENSP00000270502 | ENSP00000291536 | chromosome 19 open reading frame 52 | radial spoke head 1 homolog (Chlamydomonas); May play an important role in male meiosis (By similarity) | 0.506 |
C19orf52 | RSPH4A | ENSP00000270502 | ENSP00000229554 | chromosome 19 open reading frame 52 | radial spoke head 4 homolog A (Chlamydomonas); Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules | 0.570 |
C19orf52 | UBC | ENSP00000270502 | ENSP00000344818 | chromosome 19 open reading frame 52 | ubiquitin C | 0.721 |
CCDC114 | C19orf52 | ENSP00000318429 | ENSP00000270502 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) | chromosome 19 open reading frame 52 | 0.660 |
CCDC114 | CCDC164 | ENSP00000318429 | ENSP00000288710 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | 0.773 |
CCDC114 | CCDC39 | ENSP00000318429 | ENSP00000405708 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) | coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly | 0.659 |
CCDC114 | CCDC40 | ENSP00000318429 | ENSP00000380679 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) | coiled-coil domain containing 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39 | 0.704 |
CCDC114 | CCDC65 | ENSP00000318429 | ENSP00000312706 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) | coiled-coil domain containing 65 | 0.715 |
CCDC114 | DNAAF3 | ENSP00000318429 | ENSP00000375599 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) | dynein, axonemal, assembly factor 3; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia | 0.706 |
CCDC114 | HEATR2 | ENSP00000318429 | ENSP00000297440 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) | HEAT repeat containing 2 | 0.649 |
CCDC114 | RSPH1 | ENSP00000318429 | ENSP00000291536 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) | radial spoke head 1 homolog (Chlamydomonas); May play an important role in male meiosis (By similarity) | 0.510 |
CCDC114 | RSPH4A | ENSP00000318429 | ENSP00000229554 | coiled-coil domain containing 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms (Probable) | radial spoke head 4 homolog A (Chlamydomonas); Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules | 0.693 |
CCDC164 | C19orf52 | ENSP00000288710 | ENSP00000270502 | coiled-coil domain containing 164; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of inner dynein arm motors. May also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending | chromosome 19 open reading frame 52 | 0.700 |