KLHDC4 protein (Homo sapiens) - STRING network view

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Score

KLHDC4

kelch domain containing 4 (520 aa)

Predicted Functional Partners:

PNO1

0.868

POLR1B

0.691

ENSG00000204775

0.681

BOP1

0.681

UBC

0.639

SDAD1

0.619

F2RL1

0.601

USE1

0.601

AGAP10

0.600

BMS1

0.587

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGAP10	BOP1	ENSP00000407436	ENSP00000304151	ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential)	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.947
AGAP10	ENSG00000204775	ENSP00000407436	ENSP00000366629	ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential)	KM-PA-2 protein; Uncharacterized protein	0.947
AGAP10	KLHDC4	ENSP00000407436	ENSP00000270583	ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential)	kelch domain containing 4	0.600
AGAP10	PNO1	ENSP00000407436	ENSP00000263657	ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential)	partner of NOB1 homolog (S. cerevisiae)	0.857
AGAP10	POLR1B	ENSP00000407436	ENSP00000263331	ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential)	polymerase (RNA) I polypeptide B, 128kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)	0.941
AGAP10	SDAD1	ENSP00000407436	ENSP00000348596	ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential)	SDA1 domain containing 1; Required for 60S pre-ribosomal subunits export to the cytoplasm (By similarity)	0.951
BMS1	BOP1	ENSP00000363642	ENSP00000304151	BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.947
BMS1	ENSG00000204775	ENSP00000363642	ENSP00000366629	BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	KM-PA-2 protein; Uncharacterized protein	0.947
BMS1	KLHDC4	ENSP00000363642	ENSP00000270583	BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	kelch domain containing 4	0.587
BMS1	PNO1	ENSP00000363642	ENSP00000263657	BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	partner of NOB1 homolog (S. cerevisiae)	0.866
BMS1	POLR1B	ENSP00000363642	ENSP00000263331	BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	polymerase (RNA) I polypeptide B, 128kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)	0.954
BMS1	SDAD1	ENSP00000363642	ENSP00000348596	BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	SDA1 domain containing 1; Required for 60S pre-ribosomal subunits export to the cytoplasm (By similarity)	0.951
BMS1	UBC	ENSP00000363642	ENSP00000344818	BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	ubiquitin C	0.832
BOP1	AGAP10	ENSP00000304151	ENSP00000407436	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential)	0.947
BOP1	BMS1	ENSP00000304151	ENSP00000363642	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity)	0.947
BOP1	KLHDC4	ENSP00000304151	ENSP00000270583	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	kelch domain containing 4	0.681
BOP1	PNO1	ENSP00000304151	ENSP00000263657	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	partner of NOB1 homolog (S. cerevisiae)	0.903
BOP1	POLR1B	ENSP00000304151	ENSP00000263331	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	polymerase (RNA) I polypeptide B, 128kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)	0.975
BOP1	SDAD1	ENSP00000304151	ENSP00000348596	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	SDA1 domain containing 1; Required for 60S pre-ribosomal subunits export to the cytoplasm (By similarity)	0.935
BOP1	UBC	ENSP00000304151	ENSP00000344818	block of proliferation 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	ubiquitin C	0.433

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