node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACPT | ENPP1 | ENSP00000270593 | ENSP00000354238 | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | ectonucleotide pyrophosphatase/phosphodiesterase 1; By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. In vitro, has a broad specificity, hydrolyzing other nucleoside 5’ triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3’,5’-cAMP to AMP. May also be involved in the regu [...] | 0.912 |
ACPT | ENPP3 | ENSP00000270593 | ENSP00000350265 | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | ectonucleotide pyrophosphatase/phosphodiesterase 3; Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD (By similarity) | 0.912 |
ACPT | FLAD1 | ENSP00000270593 | ENSP00000292180 | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae); Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme | 0.900 |
ACPT | GRM4 | ENSP00000270593 | ENSP00000363296 | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | glutamate receptor, metabotropic 4; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | 0.722 |
ACPT | GRM7 | ENSP00000270593 | ENSP00000350348 | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | glutamate receptor, metabotropic 7; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | 0.649 |
ACPT | GRM8 | ENSP00000270593 | ENSP00000344173 | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | glutamate receptor, metabotropic 8 | 0.659 |
ACPT | KLK1 | ENSP00000270593 | ENSP00000301420 | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | kallikrein 1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin | 0.682 |
ACPT | KLK12 | ENSP00000270593 | ENSP00000250351 | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | kallikrein-related peptidase 12 | 0.641 |
ACPT | KLK14 | ENSP00000270593 | ENSP00000156499 | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | kallikrein-related peptidase 14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumo [...] | 0.594 |
ACPT | KLK4 | ENSP00000270593 | ENSP00000326159 | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | kallikrein-related peptidase 4; Involved in enamel formation | 0.608 |
ENPP1 | ACPT | ENSP00000354238 | ENSP00000270593 | ectonucleotide pyrophosphatase/phosphodiesterase 1; By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. In vitro, has a broad specificity, hydrolyzing other nucleoside 5’ triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3’,5’-cAMP to AMP. May also be involved in the regu [...] | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | 0.912 |
ENPP1 | FLAD1 | ENSP00000354238 | ENSP00000292180 | ectonucleotide pyrophosphatase/phosphodiesterase 1; By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. In vitro, has a broad specificity, hydrolyzing other nucleoside 5’ triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3’,5’-cAMP to AMP. May also be involved in the regu [...] | FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae); Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme | 0.901 |
ENPP3 | ACPT | ENSP00000350265 | ENSP00000270593 | ectonucleotide pyrophosphatase/phosphodiesterase 3; Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD (By similarity) | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | 0.912 |
FLAD1 | ACPT | ENSP00000292180 | ENSP00000270593 | FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae); Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | 0.900 |
FLAD1 | ENPP1 | ENSP00000292180 | ENSP00000354238 | FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae); Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme | ectonucleotide pyrophosphatase/phosphodiesterase 1; By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. PPi inhibits mineralization by binding to nascent hydroxyapatite (HA) crystals, thereby preventing further growth of these crystals. In vitro, has a broad specificity, hydrolyzing other nucleoside 5’ triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3’,5’-cAMP to AMP. May also be involved in the regu [...] | 0.901 |
GRM4 | ACPT | ENSP00000363296 | ENSP00000270593 | glutamate receptor, metabotropic 4; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | 0.722 |
GRM4 | GRM7 | ENSP00000363296 | ENSP00000350348 | glutamate receptor, metabotropic 4; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | glutamate receptor, metabotropic 7; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | 0.901 |
GRM4 | GRM8 | ENSP00000363296 | ENSP00000344173 | glutamate receptor, metabotropic 4; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | glutamate receptor, metabotropic 8 | 0.901 |
GRM7 | ACPT | ENSP00000350348 | ENSP00000270593 | glutamate receptor, metabotropic 7; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | acid phosphatase, testicular; Dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage | 0.649 |
GRM7 | GRM4 | ENSP00000350348 | ENSP00000363296 | glutamate receptor, metabotropic 7; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | glutamate receptor, metabotropic 4; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | 0.901 |