node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABL2 | ARHGEF19 | ENSP00000427562 | ENSP00000270747 | v-abl Abelson murine leukemia viral oncogene homolog 2 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | 0.530 |
ABL2 | DVL1 | ENSP00000427562 | ENSP00000368169 | v-abl Abelson murine leukemia viral oncogene homolog 2 | dishevelled, dsh homolog 1 (Drosophila); Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) | 0.830 |
ABL2 | RAC1 | ENSP00000427562 | ENSP00000348461 | v-abl Abelson murine leukemia viral oncogene homolog 2 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.932 |
ABL2 | RHOA | ENSP00000427562 | ENSP00000400175 | v-abl Abelson murine leukemia viral oncogene homolog 2 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.720 |
ARHGEF19 | ABL2 | ENSP00000270747 | ENSP00000427562 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | v-abl Abelson murine leukemia viral oncogene homolog 2 | 0.530 |
ARHGEF19 | DAAM1 | ENSP00000270747 | ENSP00000247170 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | dishevelled associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments | 0.798 |
ARHGEF19 | DVL1 | ENSP00000270747 | ENSP00000368169 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | dishevelled, dsh homolog 1 (Drosophila); Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) | 0.939 |
ARHGEF19 | FGR | ENSP00000270747 | ENSP00000363115 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FC [...] | 0.618 |
ARHGEF19 | FRK | ENSP00000270747 | ENSP00000357615 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | fyn-related kinase; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on ’Tyr-336’, which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor | 0.618 |
ARHGEF19 | FYN | ENSP00000270747 | ENSP00000346671 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] | 0.618 |
ARHGEF19 | RAC1 | ENSP00000270747 | ENSP00000348461 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.774 |
ARHGEF19 | RHOA | ENSP00000270747 | ENSP00000400175 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.787 |
ARHGEF19 | SRC | ENSP00000270747 | ENSP00000350941 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.625 |
ARHGEF19 | YES1 | ENSP00000270747 | ENSP00000324740 | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific j [...] | 0.618 |
DAAM1 | ARHGEF19 | ENSP00000247170 | ENSP00000270747 | dishevelled associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments | Rho guanine nucleotide exchange factor (GEF) 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase (By similarity) | 0.798 |
DAAM1 | DVL1 | ENSP00000247170 | ENSP00000368169 | dishevelled associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments | dishevelled, dsh homolog 1 (Drosophila); Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) | 0.997 |
DAAM1 | RAC1 | ENSP00000247170 | ENSP00000348461 | dishevelled associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.778 |
DAAM1 | RHOA | ENSP00000247170 | ENSP00000400175 | dishevelled associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.999 |
DAAM1 | SRC | ENSP00000247170 | ENSP00000350941 | dishevelled associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] | 0.702 |
DVL1 | ABL2 | ENSP00000368169 | ENSP00000427562 | dishevelled, dsh homolog 1 (Drosophila); Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) | v-abl Abelson murine leukemia viral oncogene homolog 2 | 0.830 |