node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL10RA | IL10RB | ENSP00000227752 | ENSP00000290200 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | 0.991 |
IL10RA | IL20 | ENSP00000227752 | ENSP00000356063 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | 0.854 |
IL10RA | IL22 | ENSP00000227752 | ENSP00000329384 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | 0.948 |
IL10RA | IL22RA1 | ENSP00000227752 | ENSP00000270800 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | interleukin 22 receptor, alpha 1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation | 0.964 |
IL10RA | JAK1 | ENSP00000227752 | ENSP00000343204 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.996 |
IL10RA | STAT1 | ENSP00000227752 | ENSP00000354394 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | signal transducer and activator of transcription 1, 91kDa | 0.952 |
IL10RA | STAT3 | ENSP00000227752 | ENSP00000264657 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity | 0.959 |
IL10RA | STAT5A | ENSP00000227752 | ENSP00000341208 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation | 0.936 |
IL10RA | STAT5B | ENSP00000227752 | ENSP00000293328 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | signal transducer and activator of transcription 5B; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription | 0.935 |
IL10RA | TYK2 | ENSP00000227752 | ENSP00000264818 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain | 0.954 |
IL10RB | IL10RA | ENSP00000290200 | ENSP00000227752 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | 0.991 |
IL10RB | IL20 | ENSP00000290200 | ENSP00000356063 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | 0.400 |
IL10RB | IL22 | ENSP00000290200 | ENSP00000329384 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | 0.984 |
IL10RB | IL22RA1 | ENSP00000290200 | ENSP00000270800 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | interleukin 22 receptor, alpha 1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation | 0.945 |
IL10RB | JAK1 | ENSP00000290200 | ENSP00000343204 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.938 |
IL10RB | STAT1 | ENSP00000290200 | ENSP00000354394 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | signal transducer and activator of transcription 1, 91kDa | 0.499 |
IL10RB | STAT3 | ENSP00000290200 | ENSP00000264657 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity | 0.483 |
IL10RB | TYK2 | ENSP00000290200 | ENSP00000264818 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain | 0.459 |
IL20 | IL10RA | ENSP00000356063 | ENSP00000227752 | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity | 0.854 |
IL20 | IL10RB | ENSP00000356063 | ENSP00000290200 | interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | 0.400 |