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STAT1 STAT1 STAT5A STAT5A TYK2 TYK2 STAT3 STAT3 IL10RA IL10RA IL22 IL22 STAT5B STAT5B IL20 IL20 IL22RA1 IL22RA1 JAK1 JAK1 IL10RB IL10RB
"IL22RA1" - interleukin 22 receptor, alpha 1 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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IL22RA1interleukin 22 receptor, alpha 1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation (574 aa)    
Predicted Functional Partners:
IL22
interleukin 22; Cytokine that contributes to the inflammatory response in vivo (179 aa)
        score_image score_image score_image   0.999
IL10RA
interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity (578 aa)
          score_image score_image   0.964
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (770 aa)
        score_image score_image score_image   0.959
STAT1
signal transducer and activator of transcription 1, 91kDa (750 aa)
          score_image score_image   0.949
IL20
interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 (176 aa)
          score_image score_image   0.947
IL10RB
interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 (325 aa)
            score_image   0.945
STAT5A
signal transducer and activator of transcription 5A; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (794 aa)
          score_image score_image   0.941
STAT5B
signal transducer and activator of transcription 5B; Carries out a dual function- signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription (787 aa)
          score_image score_image   0.941
TYK2
tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain (1187 aa)
          score_image score_image   0.929
JAK1
Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor (1154 aa)
          score_image score_image   0.929
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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