| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EDN1 | F2R | ENSP00000368683 | ENSP00000321326 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | 0.948 |
| EDN1 | GNRH1 | ENSP00000368683 | ENSP00000276414 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | 0.939 |
| EDN1 | GRP | ENSP00000368683 | ENSP00000256857 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity) | 0.951 |
| EDN1 | HTR2B | ENSP00000368683 | ENSP00000258400 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior | 0.939 |
| EDN1 | KISS1 | ENSP00000368683 | ENSP00000356162 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | KiSS-1 metastasis-suppressor; Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophobl [...] | 0.902 |
| EDN1 | MLN | ENSP00000368683 | ENSP00000388825 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | motilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle | 0.911 |
| EDN1 | OXT | ENSP00000368683 | ENSP00000217386 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin | 0.961 |
| EDN1 | PROK1 | ENSP00000368683 | ENSP00000271331 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | prokineticin 1; Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. [...] | 0.914 |
| EDN1 | PROKR1 | ENSP00000368683 | ENSP00000303775 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | prokineticin receptor 1; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase | 0.901 |
| EDN1 | PROKR2 | ENSP00000368683 | ENSP00000217270 | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | prokineticin receptor 2; Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase | 0.900 |
| F2R | EDN1 | ENSP00000321326 | ENSP00000368683 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | endothelin 1; Endothelins are endothelium-derived vasoconstrictor peptides | 0.948 |
| F2R | GNRH1 | ENSP00000321326 | ENSP00000276414 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | 0.907 |
| F2R | GRP | ENSP00000321326 | ENSP00000256857 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | gastrin-releasing peptide; GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP- receptor gene expression, long-term potentiation, and amygdala- dependent memory for fear (By similarity) | 0.983 |
| F2R | HTR2B | ENSP00000321326 | ENSP00000258400 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior | 0.902 |
| F2R | KISS1 | ENSP00000321326 | ENSP00000356162 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | KiSS-1 metastasis-suppressor; Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophobl [...] | 0.900 |
| F2R | MLN | ENSP00000321326 | ENSP00000388825 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | motilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle | 0.900 |
| F2R | OXT | ENSP00000321326 | ENSP00000217386 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | oxytocin/neurophysin I prepropeptide; Neurophysin 1 specifically binds oxytocin | 0.912 |
| F2R | PROK1 | ENSP00000321326 | ENSP00000271331 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | prokineticin 1; Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. [...] | 0.910 |
| F2R | PROKR1 | ENSP00000321326 | ENSP00000303775 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | prokineticin receptor 1; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase | 0.906 |
| F2R | PROKR2 | ENSP00000321326 | ENSP00000217270 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | prokineticin receptor 2; Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase | 0.900 |
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