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SORCS2 SORCS2 SORT1 SORT1 PSRC1 PSRC1 SORCS3 SORCS3 SORCS1 SORCS1 CELSR2 CELSR2 STMN1 STMN1 VANGL2 VANGL2 FZD3 FZD3 PRICKLE2 PRICKLE2 VANGL1 VANGL1
"CELSR2" - cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) in Homo sapiens
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protein of unknown 3D structure
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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CELSR2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation (2923 aa)    
Predicted Functional Partners:
VANGL2
vang-like 2 (van gogh, Drosophila); Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity) (521 aa)
        score_image   score_image   0.844
PSRC1
proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (333 aa)
            score_image   0.813
VANGL1
vang-like 1 (van gogh, Drosophila) (524 aa)
        score_image   score_image   0.809
STMN1
stathmin 1; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity) (174 aa)
            score_image   0.759
SORT1
sortilin 1; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic diff [...] (831 aa)
            score_image   0.757
FZD3
frizzled family receptor 3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] (666 aa)
        score_image   score_image   0.734
PRICKLE2
prickle homolog 2 (Drosophila) (844 aa)
            score_image   0.724
SORCS2
sortilin-related VPS10 domain containing receptor 2 (1159 aa)
            score_image   0.681
SORCS1
sortilin-related VPS10 domain containing receptor 1 (1198 aa)
            score_image   0.681
SORCS3
sortilin-related VPS10 domain containing receptor 3 (1222 aa)
            score_image   0.680
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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