node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CARK | CECR2 | ENSP00000450895 | ENSP00000262608 | FPGT-TNNI3K readthrough; May play a role in cardiac physiology | cat eye syndrome chromosome region, candidate 2; Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis | 0.633 |
CARK | GPR161 | ENSP00000450895 | ENSP00000271357 | FPGT-TNNI3K readthrough; May play a role in cardiac physiology | G protein-coupled receptor 161 | 0.555 |
CD81 | GPR161 | ENSP00000263645 | ENSP00000271357 | CD81 molecule; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV | G protein-coupled receptor 161 | 0.820 |
CECR2 | CARK | ENSP00000262608 | ENSP00000450895 | cat eye syndrome chromosome region, candidate 2; Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis | FPGT-TNNI3K readthrough; May play a role in cardiac physiology | 0.633 |
CECR2 | GPR161 | ENSP00000262608 | ENSP00000271357 | cat eye syndrome chromosome region, candidate 2; Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis | G protein-coupled receptor 161 | 0.569 |
CECR2 | TNNI3K | ENSP00000262608 | ENSP00000359928 | cat eye syndrome chromosome region, candidate 2; Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis | TNNI3 interacting kinase; May play a role in cardiac physiology | 0.627 |
FOXE3 | GPR161 | ENSP00000334472 | ENSP00000271357 | forkhead box E3 | G protein-coupled receptor 161 | 0.871 |
GPR161 | CARK | ENSP00000271357 | ENSP00000450895 | G protein-coupled receptor 161 | FPGT-TNNI3K readthrough; May play a role in cardiac physiology | 0.555 |
GPR161 | CD81 | ENSP00000271357 | ENSP00000263645 | G protein-coupled receptor 161 | CD81 molecule; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV | 0.820 |
GPR161 | CECR2 | ENSP00000271357 | ENSP00000262608 | G protein-coupled receptor 161 | cat eye syndrome chromosome region, candidate 2; Part of the CERF (CECR2-containing-remodeling factor) complex, which facilitates the perturbation of chromatin structure in an ATP-dependent manner. May be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis | 0.569 |
GPR161 | FOXE3 | ENSP00000271357 | ENSP00000334472 | G protein-coupled receptor 161 | forkhead box E3 | 0.871 |
GPR161 | GPR88 | ENSP00000271357 | ENSP00000314223 | G protein-coupled receptor 161 | G protein-coupled receptor 88; Orphan receptor | 0.490 |
GPR161 | PRKACA | ENSP00000271357 | ENSP00000309591 | G protein-coupled receptor 161 | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | 0.565 |
GPR161 | TMEM87A | ENSP00000271357 | ENSP00000374484 | G protein-coupled receptor 161 | transmembrane protein 87A | 0.583 |
GPR161 | TMEM87B | ENSP00000271357 | ENSP00000283206 | G protein-coupled receptor 161 | transmembrane protein 87B | 0.605 |
GPR161 | TNNI3K | ENSP00000271357 | ENSP00000359928 | G protein-coupled receptor 161 | TNNI3 interacting kinase; May play a role in cardiac physiology | 0.550 |
GPR161 | TULP3 | ENSP00000271357 | ENSP00000380321 | G protein-coupled receptor 161 | tubby like protein 3; Negative regulator of the Shh signaling transduction pathway- recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis | 0.530 |
GPR88 | GPR161 | ENSP00000314223 | ENSP00000271357 | G protein-coupled receptor 88; Orphan receptor | G protein-coupled receptor 161 | 0.490 |
PRKACA | GPR161 | ENSP00000309591 | ENSP00000271357 | protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...] | G protein-coupled receptor 161 | 0.565 |
TMEM87A | GPR161 | ENSP00000374484 | ENSP00000271357 | transmembrane protein 87A | G protein-coupled receptor 161 | 0.583 |