node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP19 | PRUNE | ENSP00000351333 | ENSP00000271620 | Rho GTPase activating protein 19 | prune homolog (Drosophila) | 0.661 |
BNIP2 | PRUNE | ENSP00000267859 | ENSP00000271620 | BCL2/adenovirus E1B 19kDa interacting protein 2; Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins | prune homolog (Drosophila) | 0.635 |
CHST1 | PRUNE | ENSP00000309270 | ENSP00000271620 | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains att [...] | prune homolog (Drosophila) | 0.450 |
GSK3B | PRUNE | ENSP00000324806 | ENSP00000271620 | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | prune homolog (Drosophila) | 0.750 |
GTF2IRD1 | PRUNE | ENSP00000397566 | ENSP00000271620 | GTF2I repeat domain containing 1 | prune homolog (Drosophila) | 0.546 |
GTF2IRD1 | WBSCR22 | ENSP00000397566 | ENSP00000401191 | GTF2I repeat domain containing 1 | Williams Beuren syndrome chromosome region 22 | 0.556 |
HDDC3 | NME1 | ENSP00000330721 | ENSP00000013034 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination | 0.902 |
HDDC3 | PRUNE | ENSP00000330721 | ENSP00000271620 | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | prune homolog (Drosophila) | 0.900 |
JTB | PRUNE | ENSP00000271843 | ENSP00000271620 | jumping translocation breakpoint; Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mi [...] | prune homolog (Drosophila) | 0.441 |
NBPF4 | PRUNE | ENSP00000359055 | ENSP00000271620 | neuroblastoma breakpoint family, member 4 | prune homolog (Drosophila) | 0.457 |
NME1 | HDDC3 | ENSP00000013034 | ENSP00000330721 | NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | 0.902 |
NME1 | PRUNE | ENSP00000013034 | ENSP00000271620 | NME/NM23 nucleoside diphosphate kinase 1; Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3’-5’ exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination | prune homolog (Drosophila) | 0.902 |
PRUNE | ARHGAP19 | ENSP00000271620 | ENSP00000351333 | prune homolog (Drosophila) | Rho GTPase activating protein 19 | 0.661 |
PRUNE | BNIP2 | ENSP00000271620 | ENSP00000267859 | prune homolog (Drosophila) | BCL2/adenovirus E1B 19kDa interacting protein 2; Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins | 0.635 |
PRUNE | CHST1 | ENSP00000271620 | ENSP00000309270 | prune homolog (Drosophila) | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N- acetyllactosamine oligosaccharide chains att [...] | 0.450 |
PRUNE | GSK3B | ENSP00000271620 | ENSP00000324806 | prune homolog (Drosophila) | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | 0.750 |
PRUNE | GTF2IRD1 | ENSP00000271620 | ENSP00000397566 | prune homolog (Drosophila) | GTF2I repeat domain containing 1 | 0.546 |
PRUNE | HDDC3 | ENSP00000271620 | ENSP00000330721 | prune homolog (Drosophila) | HD domain containing 3; ppGpp hydrolyzing enzyme involved in starvation response | 0.900 |
PRUNE | JTB | ENSP00000271620 | ENSP00000271843 | prune homolog (Drosophila) | jumping translocation breakpoint; Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mi [...] | 0.441 |
PRUNE | NBPF4 | ENSP00000271620 | ENSP00000359055 | prune homolog (Drosophila) | neuroblastoma breakpoint family, member 4 | 0.457 |