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DBF4 DBF4 CDCA7L CDCA7L ZMYM2 ZMYM2 PSIP1 PSIP1 POGZ POGZ ZMYM4 ZMYM4 ZMYM6 ZMYM6 UBC UBC QRICH1 QRICH1 ZMYM3 ZMYM3 CBX5 CBX5
"POGZ" - pogo transposable element with ZNF domain in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
Coexpression
Experiments
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[Homology]
Score
POGZpogo transposable element with ZNF domain (1410 aa)    
Predicted Functional Partners:
ZMYM3
zinc finger, MYM-type 3; Plays a role in the regulation of cell morphology and cytoskeletal organization (1370 aa)
         score_image   score_image   0.820
ZMYM6
zinc finger, MYM-type 6 (1325 aa)
         score_image   score_image   0.806
ZMYM2
zinc finger, MYM-type 2 (1377 aa)
         score_image   score_image   0.805
ZMYM4
zinc finger, MYM-type 4; Plays a role in the regulation of cell morphology and cytoskeletal organization (1548 aa)
         score_image   score_image   0.805
CDCA7L
cell division cycle associated 7-like (454 aa)
             score_image   0.785
PSIP1
PC4 and SFRS1 interacting protein 1; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration (530 aa)
       score_image     score_image   0.761
QRICH1
glutamine-rich 1 (776 aa)
         score_image   score_image   0.760
CBX5
chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (191 aa)
         score_image   score_image   0.734
UBC
ubiquitin C (685 aa)
         score_image   score_image   0.685
DBF4
DBF4 homolog (S. cerevisiae); Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at ’Ser-40’ and ’Ser-53’ and then is involved in regulating the initiation of DNA replication during cell cycle (674 aa)
       score_image     score_image   0.629
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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