LBR protein (Homo sapiens) - STRING network view

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LBR

lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane (615 aa)

Predicted Functional Partners:

CYP51A1

0.992

CBX5

0.977

SRPK1

0.974

SC5DL

0.971

MSMO1

0.971

UBC

0.932

EIF4A3

0.902

HSD17B7

0.894

SQLE

0.876

CDK1

0.864

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBX5	LBR	ENSP00000209875	ENSP00000272163	chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins	lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane	0.977
CBX5	SRPK1	ENSP00000209875	ENSP00000362931	chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	0.478
CBX5	UBC	ENSP00000209875	ENSP00000344818	chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins	ubiquitin C	0.853
CDK1	LBR	ENSP00000378699	ENSP00000272163	cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...]	lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane	0.864
CDK1	UBC	ENSP00000378699	ENSP00000344818	cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...]	ubiquitin C	0.999
CYP51A1	HSD17B7	ENSP00000003100	ENSP00000254521	cytochrome P450, family 51, subfamily A, polypeptide 1	hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols	0.984
CYP51A1	LBR	ENSP00000003100	ENSP00000272163	cytochrome P450, family 51, subfamily A, polypeptide 1	lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane	0.992
CYP51A1	MSMO1	ENSP00000003100	ENSP00000261507	cytochrome P450, family 51, subfamily A, polypeptide 1	methylsterol monooxygenase 1	0.997
CYP51A1	SC5DL	ENSP00000003100	ENSP00000264027	cytochrome P450, family 51, subfamily A, polypeptide 1	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol	0.993
CYP51A1	SQLE	ENSP00000003100	ENSP00000265896	cytochrome P450, family 51, subfamily A, polypeptide 1	squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway	0.978
CYP51A1	UBC	ENSP00000003100	ENSP00000344818	cytochrome P450, family 51, subfamily A, polypeptide 1	ubiquitin C	0.986
EIF4A3	LBR	ENSP00000269349	ENSP00000272163	eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...]	lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane	0.902
EIF4A3	SRPK1	ENSP00000269349	ENSP00000362931	eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...]	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	0.540
EIF4A3	UBC	ENSP00000269349	ENSP00000344818	eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...]	ubiquitin C	0.994
HSD17B7	CYP51A1	ENSP00000254521	ENSP00000003100	hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols	cytochrome P450, family 51, subfamily A, polypeptide 1	0.984
HSD17B7	LBR	ENSP00000254521	ENSP00000272163	hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols	lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane	0.894
HSD17B7	MSMO1	ENSP00000254521	ENSP00000261507	hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols	methylsterol monooxygenase 1	0.998
HSD17B7	SC5DL	ENSP00000254521	ENSP00000264027	hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol	0.980
HSD17B7	SQLE	ENSP00000254521	ENSP00000265896	hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols	squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway	0.755
HSD17B7	UBC	ENSP00000254521	ENSP00000344818	hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols	ubiquitin C	0.939

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