| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1B1 | AKR1B10 | ENSP00000285930 | ENSP00000352584 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | 0.902 |
| AKR1B1 | GALK1 | ENSP00000285930 | ENSP00000225614 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | galactokinase 1; Major enzyme for galactose metabolism | 0.465 |
| AKR1B1 | GALM | ENSP00000285930 | ENSP00000272252 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | galactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.906 |
| AKR1B1 | GCK | ENSP00000285930 | ENSP00000223366 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage | 0.845 |
| AKR1B1 | GLB1 | ENSP00000285930 | ENSP00000306920 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.910 |
| AKR1B1 | HK1 | ENSP00000285930 | ENSP00000384774 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | hexokinase 1 | 0.847 |
| AKR1B1 | LCT | ENSP00000285930 | ENSP00000264162 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | lactase; LPH splits lactose in the small intestine | 0.907 |
| AKR1B10 | AKR1B1 | ENSP00000352584 | ENSP00000285930 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | 0.902 |
| AKR1B10 | GALM | ENSP00000352584 | ENSP00000272252 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | galactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.906 |
| AKR1B10 | GCK | ENSP00000352584 | ENSP00000223366 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage | 0.840 |
| AKR1B10 | GLB1 | ENSP00000352584 | ENSP00000306920 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | galactosidase, beta 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans | 0.910 |
| AKR1B10 | HK1 | ENSP00000352584 | ENSP00000384774 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | hexokinase 1 | 0.838 |
| AKR1B10 | LCT | ENSP00000352584 | ENSP00000264162 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | lactase; LPH splits lactose in the small intestine | 0.929 |
| GALE | GALK1 | ENSP00000363621 | ENSP00000225614 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | galactokinase 1; Major enzyme for galactose metabolism | 0.996 |
| GALE | GALK2 | ENSP00000363621 | ENSP00000453129 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | galactokinase 2; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates | 0.988 |
| GALE | GALM | ENSP00000363621 | ENSP00000272252 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | galactose mutarotase (aldose 1-epimerase); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) | 0.959 |
| GALE | GALT | ENSP00000363621 | ENSP00000368119 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | galactose-1-phosphate uridylyltransferase | 0.999 |
| GALE | LCT | ENSP00000363621 | ENSP00000264162 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | lactase; LPH splits lactose in the small intestine | 0.422 |
| GALK1 | AKR1B1 | ENSP00000225614 | ENSP00000285930 | galactokinase 1; Major enzyme for galactose metabolism | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | 0.465 |
| GALK1 | GALE | ENSP00000225614 | ENSP00000363621 | galactokinase 1; Major enzyme for galactose metabolism | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | 0.996 |
Share
