node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP2B4 | CACNA1C | ENSP00000350310 | ENSP00000266376 | ATPase, Ca++ transporting, plasma membrane 4; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.623 |
ATP2B4 | CALM2 | ENSP00000350310 | ENSP00000272298 | ATPase, Ca++ transporting, plasma membrane 4; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | calmodulin 2 (phosphorylase kinase, delta) | 0.963 |
ATP2B4 | SCN5A | ENSP00000350310 | ENSP00000328968 | ATPase, Ca++ transporting, plasma membrane 4; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | sodium channel, voltage-gated, type V, alpha subunit | 0.672 |
ATP2B4 | UBC | ENSP00000350310 | ENSP00000344818 | ATPase, Ca++ transporting, plasma membrane 4; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | ubiquitin C | 0.928 |
CACNA1C | ATP2B4 | ENSP00000266376 | ENSP00000350310 | calcium channel, voltage-dependent, L type, alpha 1C subunit | ATPase, Ca++ transporting, plasma membrane 4; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | 0.623 |
CACNA1C | CALM2 | ENSP00000266376 | ENSP00000272298 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calmodulin 2 (phosphorylase kinase, delta) | 0.988 |
CACNA1C | CAMK2D | ENSP00000266376 | ENSP00000339740 | calcium channel, voltage-dependent, L type, alpha 1C subunit | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] | 0.857 |
CACNA1C | UBC | ENSP00000266376 | ENSP00000344818 | calcium channel, voltage-dependent, L type, alpha 1C subunit | ubiquitin C | 0.775 |
CALM2 | ATP2B4 | ENSP00000272298 | ENSP00000350310 | calmodulin 2 (phosphorylase kinase, delta) | ATPase, Ca++ transporting, plasma membrane 4; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell | 0.963 |
CALM2 | CACNA1C | ENSP00000272298 | ENSP00000266376 | calmodulin 2 (phosphorylase kinase, delta) | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.988 |
CALM2 | CAMK2D | ENSP00000272298 | ENSP00000339740 | calmodulin 2 (phosphorylase kinase, delta) | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] | 0.961 |
CALM2 | DAPK1 | ENSP00000272298 | ENSP00000350785 | calmodulin 2 (phosphorylase kinase, delta) | death-associated protein kinase 1; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress [...] | 0.943 |
CALM2 | EGFR | ENSP00000272298 | ENSP00000275493 | calmodulin 2 (phosphorylase kinase, delta) | epidermal growth factor receptor | 0.948 |
CALM2 | IQGAP2 | ENSP00000272298 | ENSP00000274364 | calmodulin 2 (phosphorylase kinase, delta) | IQ motif containing GTPase activating protein 2; Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin | 0.980 |
CALM2 | MYO1C | ENSP00000272298 | ENSP00000352834 | calmodulin 2 (phosphorylase kinase, delta) | myosin IC; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell’s (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of ve [...] | 0.979 |
CALM2 | NOS3 | ENSP00000272298 | ENSP00000297494 | calmodulin 2 (phosphorylase kinase, delta) | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | 0.948 |
CALM2 | SCN5A | ENSP00000272298 | ENSP00000328968 | calmodulin 2 (phosphorylase kinase, delta) | sodium channel, voltage-gated, type V, alpha subunit | 0.985 |
CALM2 | UBC | ENSP00000272298 | ENSP00000344818 | calmodulin 2 (phosphorylase kinase, delta) | ubiquitin C | 0.978 |
CAMK2D | CACNA1C | ENSP00000339740 | ENSP00000266376 | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] | calcium channel, voltage-dependent, L type, alpha 1C subunit | 0.857 |
CAMK2D | CALM2 | ENSP00000339740 | ENSP00000272298 | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] | calmodulin 2 (phosphorylase kinase, delta) | 0.961 |