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ZFP3 ZFP3 CC2D2A CC2D2A TMEM67 TMEM67 WDPCP WDPCP MKS1 MKS1 BBS10 BBS10 BBS9 BBS9 BBS7 BBS7 CCDC28B CCDC28B BBS12 BBS12 BBS1 BBS1
"WDPCP" - WD repeat containing planar cell polarity effector in Homo sapiens
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WDPCPWD repeat containing planar cell polarity effector; Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements (By similarity) (746 aa)    
Predicted Functional Partners:
MKS1
Meckel syndrome, type 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology (559 aa)
            score_image   0.732
BBS1
Bardet-Biedl syndrome 1; The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of [...] (593 aa)
            score_image   0.674
CC2D2A
coiled-coil and C2 domain containing 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity) (1620 aa)
            score_image   0.658
BBS9
Bardet-Biedl syndrome 9 (887 aa)
            score_image   0.632
CCDC28B
coiled-coil domain containing 28B; Involved in ciliogenesis (200 aa)
            score_image   0.624
BBS7
Bardet-Biedl syndrome 7; The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of [...] (715 aa)
            score_image   0.616
TMEM67
transmembrane protein 67; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC) (995 aa)
            score_image   0.604
BBS12
Bardet-Biedl syndrome 12; Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation (710 aa)
            score_image   0.590
ZFP3
zinc finger protein 3 homolog (mouse); May be involved in transcriptional regulation (502 aa)
            score_image   0.569
BBS10
Bardet-Biedl syndrome 10; Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation (723 aa)
            score_image   0.563
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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