TRIM43 protein (Homo sapiens) - STRING network view

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TRIM43

tripartite motif containing 43 (446 aa)

Predicted Functional Partners:

ENOX1

0.608

H1FOO

0.565

NANOS2

0.501

MBD3L2

0.498

NANOS3

0.496

TRIM8

0.461

UBC

0.433

SSRP1

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENOX1	TRIM43	ENSP00000261488	ENSP00000272395	ecto-NOX disulfide-thiol exchanger 1; Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock	tripartite motif containing 43	0.608
H1FOO	TRIM43	ENSP00000319799	ENSP00000272395	H1 histone family, member O, oocyte-specific; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an import [...]	tripartite motif containing 43	0.565
MBD3L2	TRIM43	ENSP00000370800	ENSP00000272395	methyl-CpG binding domain protein 3-like 2	tripartite motif containing 43	0.498
NANOS2	TRIM43	ENSP00000341021	ENSP00000272395	nanos homolog 2 (Drosophila); Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. R [...]	tripartite motif containing 43	0.501
NANOS3	TRIM43	ENSP00000341992	ENSP00000272395	nanos homolog 3 (Drosophila); Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis	tripartite motif containing 43	0.496
SSRP1	TRIM43	ENSP00000278412	ENSP00000272395	structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...]	tripartite motif containing 43	0.405
SSRP1	UBC	ENSP00000278412	ENSP00000344818	structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...]	ubiquitin C	0.952
TRIM43	ENOX1	ENSP00000272395	ENSP00000261488	tripartite motif containing 43	ecto-NOX disulfide-thiol exchanger 1; Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock	0.608
TRIM43	H1FOO	ENSP00000272395	ENSP00000319799	tripartite motif containing 43	H1 histone family, member O, oocyte-specific; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an import [...]	0.565
TRIM43	MBD3L2	ENSP00000272395	ENSP00000370800	tripartite motif containing 43	methyl-CpG binding domain protein 3-like 2	0.498
TRIM43	NANOS2	ENSP00000272395	ENSP00000341021	tripartite motif containing 43	nanos homolog 2 (Drosophila); Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. R [...]	0.501
TRIM43	NANOS3	ENSP00000272395	ENSP00000341992	tripartite motif containing 43	nanos homolog 3 (Drosophila); Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis	0.496
TRIM43	SSRP1	ENSP00000272395	ENSP00000278412	tripartite motif containing 43	structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...]	0.405
TRIM43	TRIM8	ENSP00000272395	ENSP00000302120	tripartite motif containing 43	tripartite motif containing 8; Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1 (By similarity)	0.461
TRIM43	UBC	ENSP00000272395	ENSP00000344818	tripartite motif containing 43	ubiquitin C	0.433
TRIM8	TRIM43	ENSP00000302120	ENSP00000272395	tripartite motif containing 8; Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1 (By similarity)	tripartite motif containing 43	0.461
UBC	SSRP1	ENSP00000344818	ENSP00000278412	ubiquitin C	structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...]	0.952
UBC	TRIM43	ENSP00000344818	ENSP00000272395	ubiquitin C	tripartite motif containing 43	0.433

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