| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASCC3 | B3GAT2 | ENSP00000358159 | ENSP00000230053 | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S); Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity) | 0.551 |
| ASCC3 | CDC5L | ENSP00000358159 | ENSP00000360532 | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.897 |
| ASCC3 | CNPY3 | ENSP00000358159 | ENSP00000361926 | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | canopy 3 homolog (zebrafish); Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptative immune responses (By similarity) | 0.639 |
| ASCC3 | PPP2R5D | ENSP00000358159 | ENSP00000417963 | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | protein phosphatase 2, regulatory subunit B’, delta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.598 |
| ASCC3 | RARS2 | ENSP00000358159 | ENSP00000358549 | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | arginyl-tRNA synthetase 2, mitochondrial | 0.617 |
| ASCC3 | SFXN5 | ENSP00000358159 | ENSP00000272433 | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | sideroflexin 5; Transports citrate. Potential iron transporter (By similarity) | 0.629 |
| ASCC3 | UMPS | ENSP00000358159 | ENSP00000232607 | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | uridine monophosphate synthetase | 0.604 |
| B3GAT2 | ASCC3 | ENSP00000230053 | ENSP00000358159 | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S); Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity) | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | 0.551 |
| B3GAT2 | CDC5L | ENSP00000230053 | ENSP00000360532 | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S); Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity) | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.527 |
| B3GAT2 | CNPY3 | ENSP00000230053 | ENSP00000361926 | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S); Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity) | canopy 3 homolog (zebrafish); Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptative immune responses (By similarity) | 0.578 |
| B3GAT2 | PPP2R5D | ENSP00000230053 | ENSP00000417963 | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S); Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity) | protein phosphatase 2, regulatory subunit B’, delta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.406 |
| B3GAT2 | RARS2 | ENSP00000230053 | ENSP00000358549 | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S); Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity) | arginyl-tRNA synthetase 2, mitochondrial | 0.543 |
| B3GAT2 | SFXN5 | ENSP00000230053 | ENSP00000272433 | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S); Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity) | sideroflexin 5; Transports citrate. Potential iron transporter (By similarity) | 0.619 |
| B3GAT2 | UMPS | ENSP00000230053 | ENSP00000232607 | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S); Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity) | uridine monophosphate synthetase | 0.484 |
| CDC5L | ASCC3 | ENSP00000360532 | ENSP00000358159 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | activating signal cointegrator 1 complex subunit 3; 3’-5’ DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3- methylcytosine (3mC) within double-stranded regions. Enhances NF- kappa-B, SRF and AP1 transactivation | 0.897 |
| CDC5L | B3GAT2 | ENSP00000360532 | ENSP00000230053 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S); Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins (By similarity) | 0.527 |
| CDC5L | CNPY3 | ENSP00000360532 | ENSP00000361926 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | canopy 3 homolog (zebrafish); Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptative immune responses (By similarity) | 0.536 |
| CDC5L | PPP2R5D | ENSP00000360532 | ENSP00000417963 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | protein phosphatase 2, regulatory subunit B’, delta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment | 0.425 |
| CDC5L | SFXN5 | ENSP00000360532 | ENSP00000272433 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | sideroflexin 5; Transports citrate. Potential iron transporter (By similarity) | 0.505 |
| CDC5L | SNRNP200 | ENSP00000360532 | ENSP00000317123 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | small nuclear ribonucleoprotein 200kDa (U5); RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome | 0.997 |
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