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NRXN1 NRXN1 DPH1 DPH1 SEPT9 SEPT9 SMIM5 SMIM5 ENSG00000214014 ENSG00000214014 OVCA2 OVCA2 NXPH2 NXPH2 TMEM52B TMEM52B ITGA2 ITGA2 NPS NPS SPOPL SPOPL
"NXPH2" - neurexophilin 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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protein homology
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NXPH2neurexophilin 2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors (Potential) (264 aa)    
Predicted Functional Partners:
NRXN1
neurexin 1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity) (1547 aa)
        score_image   score_image   0.698
NPS
neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) (89 aa)
            score_image   0.681
OVCA2
ovarian tumor suppressor candidate 2 (227 aa)
            score_image   0.608
ENSG00000214014
Ovarian cancer-associated gene 2 protein (227 aa)
            score_image   0.608
SMIM5
small integral membrane protein 5 (77 aa)
            score_image   0.585
SEPT9
septin 9 (586 aa)
            score_image   0.561
DPH1
DPH1 homolog (S. cerevisiae); Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival (By similarity) (443 aa)
            score_image   0.560
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix (1181 aa)
            score_image   0.511
TMEM52B
transmembrane protein 52B (163 aa)
            score_image   0.506
SPOPL
speckle-type POZ protein-like; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes [...] (392 aa)
            score_image   0.506
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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