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STRINGSTRING
PRSS46 PRSS46 TMPRSS5 TMPRSS5 TBC1D26 TBC1D26 APOBEC3F APOBEC3F ADAM20 ADAM20 CPO CPO TPSD1 TPSD1 CPXM2 CPXM2 ATP6V0D2 ATP6V0D2 AGTPBP1 AGTPBP1 ATP6V0D1 ATP6V0D1
"CPO" - carboxypeptidase O in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
CPOcarboxypeptidase O; Probable carboxypeptidase which may cleave proteins with C-terminal acidic residues (By similarity) (374 aa)    
Predicted Functional Partners:
CPXM2
carboxypeptidase X (M14 family), member 2; May be involved in cell-cell interactions (756 aa)
            score_image   0.577
TBC1D26
TBC1 domain family, member 26; May act as a GTPase-activating protein for Rab family protein(s) (Potential) (250 aa)
            score_image   0.569
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity) (351 aa)
      score_image         0.567
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity) (350 aa)
      score_image         0.567
TPSD1
tryptase delta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity) (242 aa)
            score_image   0.501
TMPRSS5
transmembrane protease, serine 5; May play a role in hearing (457 aa)
            score_image   0.448
PRSS46
protease, serine, 46 (174 aa)
            score_image   0.423
ADAM20
ADAM metallopeptidase domain 20; May be involved in sperm maturation and/or fertilization (776 aa)
            score_image   0.420
AGTPBP1
ATP/GTP binding protein 1 (1186 aa)
            score_image   0.416
APOBEC3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. T [...] (373 aa)
            score_image   0.407
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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