| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DNAJC19 | PAM16 | ENSP00000372005 | ENSP00000315693 | DnaJ (Hsp40) homolog, subfamily C, member 19; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity) | presequence translocase-associated motor 16 homolog (S. cerevisiae); Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity | 0.999 |
| DNAJC19 | TAMM41 | ENSP00000372005 | ENSP00000273037 | DnaJ (Hsp40) homolog, subfamily C, member 19; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity) | TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae); May be involved in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane (By similarity) | 0.629 |
| DNAJC19 | TIMM21 | ENSP00000372005 | ENSP00000169551 | DnaJ (Hsp40) homolog, subfamily C, member 19; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity) | translocase of inner mitochondrial membrane 21 homolog (yeast); Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes | 0.993 |
| DNAJC19 | TIMM23 | ENSP00000372005 | ENSP00000260867 | DnaJ (Hsp40) homolog, subfamily C, member 19; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity) | translocase of inner mitochondrial membrane 23 homolog (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane | 0.952 |
| FAM46D | SMCR7L | ENSP00000308575 | ENSP00000327124 | family with sequence similarity 46, member D | Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission | 0.697 |
| FAM46D | STRBP | ENSP00000308575 | ENSP00000321347 | family with sequence similarity 46, member D | spermatid perinuclear RNA binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I-C) RNA than to poly(dI-dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3’-UTR and adenovirus VA RNA (By similarity) | 0.632 |
| FAM46D | TAMM41 | ENSP00000308575 | ENSP00000273037 | family with sequence similarity 46, member D | TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae); May be involved in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane (By similarity) | 0.712 |
| NDUFAF7 | TAMM41 | ENSP00000002125 | ENSP00000273037 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 7; Involved in the assembly or stability of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) | TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae); May be involved in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane (By similarity) | 0.722 |
| PAM16 | DNAJC19 | ENSP00000315693 | ENSP00000372005 | presequence translocase-associated motor 16 homolog (S. cerevisiae); Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity | DnaJ (Hsp40) homolog, subfamily C, member 19; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity) | 0.999 |
| PAM16 | TAMM41 | ENSP00000315693 | ENSP00000273037 | presequence translocase-associated motor 16 homolog (S. cerevisiae); Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity | TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae); May be involved in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane (By similarity) | 0.687 |
| PAM16 | TIMM21 | ENSP00000315693 | ENSP00000169551 | presequence translocase-associated motor 16 homolog (S. cerevisiae); Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity | translocase of inner mitochondrial membrane 21 homolog (yeast); Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes | 0.994 |
| PAM16 | TIMM23 | ENSP00000315693 | ENSP00000260867 | presequence translocase-associated motor 16 homolog (S. cerevisiae); Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity | translocase of inner mitochondrial membrane 23 homolog (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane | 0.997 |
| PRELID1 | TAMM41 | ENSP00000302114 | ENSP00000273037 | PRELI domain containing 1; May be important for the development of vital and immunocompetent organs | TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae); May be involved in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane (By similarity) | 0.622 |
| SLC25A41 | TAMM41 | ENSP00000322649 | ENSP00000273037 | solute carrier family 25, member 41 | TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae); May be involved in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane (By similarity) | 0.793 |
| SMCR7L | FAM46D | ENSP00000327124 | ENSP00000308575 | Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission | family with sequence similarity 46, member D | 0.697 |
| SMCR7L | STRBP | ENSP00000327124 | ENSP00000321347 | Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission | spermatid perinuclear RNA binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I-C) RNA than to poly(dI-dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3’-UTR and adenovirus VA RNA (By similarity) | 0.625 |
| SMCR7L | TAMM41 | ENSP00000327124 | ENSP00000273037 | Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission | TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae); May be involved in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane (By similarity) | 0.699 |
| SMCR7L | TIMM23 | ENSP00000327124 | ENSP00000260867 | Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission | translocase of inner mitochondrial membrane 23 homolog (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane | 0.634 |
| STRBP | FAM46D | ENSP00000321347 | ENSP00000308575 | spermatid perinuclear RNA binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I-C) RNA than to poly(dI-dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3’-UTR and adenovirus VA RNA (By similarity) | family with sequence similarity 46, member D | 0.632 |
| STRBP | SMCR7L | ENSP00000321347 | ENSP00000327124 | spermatid perinuclear RNA binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I-C) RNA than to poly(dI-dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3’-UTR and adenovirus VA RNA (By similarity) | Smith-Magenis syndrome chromosome region, candidate 7-like; Mitochondrial outer membrane protein which regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposites processes- fusion and fission. Seems to have a key role in inhibiting DNM1L-induced mitochondrial fission | 0.625 |
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