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STRINGSTRING
GAD1 GAD1 GPA33 GPA33 ASIC4 ASIC4 ENO3 ENO3 PNKD PNKD MYL12B MYL12B MYL2 MYL2 MYL9 MYL9 MAPK3 MAPK3 THAP1 THAP1 PRRT2 PRRT2
"PNKD" - paroxysmal nonkinesigenic dyskinesia in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
PNKDparoxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) (385 aa)    
Predicted Functional Partners:
GPA33
glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling (319 aa)
            score_image   0.868
ASIC4
acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity (647 aa)
            score_image   0.860
MYL2
myosin, light chain 2, regulatory, cardiac, slow (166 aa)
            score_image   0.833
MYL9
myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (172 aa)
            score_image   0.829
THAP1
THAP domain containing, apoptosis associated protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5’-[AT]NTNN[GT]GGCA[AGT]-3’ core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (213 aa)
            score_image   0.767
PRRT2
proline-rich transmembrane protein 2 (340 aa)
            score_image   0.756
MAPK3
mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] (379 aa)
        score_image   score_image   0.604
MYL12B
myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) (172 aa)
        score_image   score_image   0.580
ENO3
enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration (434 aa)
        score_image       0.576
GAD1
glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA (594 aa)
            score_image   0.562
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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