node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASIC4 | GPA33 | ENSP00000326627 | ENSP00000356842 | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | 0.816 |
ASIC4 | PNKD | ENSP00000326627 | ENSP00000273077 | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | 0.860 |
ENO3 | PNKD | ENSP00000324105 | ENSP00000273077 | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | 0.576 |
GAD1 | PNKD | ENSP00000350928 | ENSP00000273077 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | 0.562 |
GPA33 | ASIC4 | ENSP00000356842 | ENSP00000326627 | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | 0.816 |
GPA33 | PNKD | ENSP00000356842 | ENSP00000273077 | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | 0.868 |
MAPK3 | PNKD | ENSP00000263025 | ENSP00000273077 | mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | 0.604 |
MYL12B | MYL9 | ENSP00000237500 | ENSP00000279022 | myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | 0.900 |
MYL12B | PNKD | ENSP00000237500 | ENSP00000273077 | myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | 0.580 |
MYL2 | PNKD | ENSP00000228841 | ENSP00000273077 | myosin, light chain 2, regulatory, cardiac, slow | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | 0.833 |
MYL9 | MYL12B | ENSP00000279022 | ENSP00000237500 | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | 0.900 |
MYL9 | PNKD | ENSP00000279022 | ENSP00000273077 | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | 0.829 |
PNKD | ASIC4 | ENSP00000273077 | ENSP00000326627 | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | 0.860 |
PNKD | ENO3 | ENSP00000273077 | ENSP00000324105 | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | 0.576 |
PNKD | GAD1 | ENSP00000273077 | ENSP00000350928 | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.562 |
PNKD | GPA33 | ENSP00000273077 | ENSP00000356842 | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | 0.868 |
PNKD | MAPK3 | ENSP00000273077 | ENSP00000263025 | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.604 |
PNKD | MYL12B | ENSP00000273077 | ENSP00000237500 | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | 0.580 |
PNKD | MYL2 | ENSP00000273077 | ENSP00000228841 | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | myosin, light chain 2, regulatory, cardiac, slow | 0.833 |
PNKD | MYL9 | ENSP00000273077 | ENSP00000279022 | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | 0.829 |