| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADAMTS6 | ARL5B | ENSP00000370443 | ENSP00000366487 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | ADP-ribosylation factor-like 5B; Binds and exchanges GTP and GDP | 0.408 |
| ADAMTS6 | CSRNP1 | ENSP00000370443 | ENSP00000273153 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | 0.514 |
| ARL5B | ADAMTS6 | ENSP00000366487 | ENSP00000370443 | ADP-ribosylation factor-like 5B; Binds and exchanges GTP and GDP | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.408 |
| ARL5B | CSRNP1 | ENSP00000366487 | ENSP00000273153 | ADP-ribosylation factor-like 5B; Binds and exchanges GTP and GDP | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | 0.506 |
| ARL5B | GPR171 | ENSP00000366487 | ENSP00000308479 | ADP-ribosylation factor-like 5B; Binds and exchanges GTP and GDP | G protein-coupled receptor 171; Orphan receptor | 0.526 |
| ARL5B | RASL11B | ENSP00000366487 | ENSP00000248706 | ADP-ribosylation factor-like 5B; Binds and exchanges GTP and GDP | RAS-like, family 11, member B | 0.447 |
| AXIN1 | CSRNP1 | ENSP00000262320 | ENSP00000273153 | axin 1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet i [...] | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | 0.603 |
| AXIN1 | PPP1CA | ENSP00000262320 | ENSP00000326031 | axin 1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet i [...] | protein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] | 0.597 |
| AXIN1 | PPP1CC | ENSP00000262320 | ENSP00000335084 | axin 1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet i [...] | protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca [...] | 0.545 |
| CSRNP1 | ADAMTS6 | ENSP00000273153 | ENSP00000370443 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.514 |
| CSRNP1 | ARL5B | ENSP00000273153 | ENSP00000366487 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | ADP-ribosylation factor-like 5B; Binds and exchanges GTP and GDP | 0.506 |
| CSRNP1 | AXIN1 | ENSP00000273153 | ENSP00000262320 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | axin 1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet i [...] | 0.603 |
| CSRNP1 | GPR171 | ENSP00000273153 | ENSP00000308479 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | G protein-coupled receptor 171; Orphan receptor | 0.539 |
| CSRNP1 | PPP1CA | ENSP00000273153 | ENSP00000326031 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | protein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] | 0.587 |
| CSRNP1 | PPP1CC | ENSP00000273153 | ENSP00000335084 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca [...] | 0.616 |
| CSRNP1 | RASL11B | ENSP00000273153 | ENSP00000248706 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | RAS-like, family 11, member B | 0.485 |
| CSRNP1 | SLCO5A1 | ENSP00000273153 | ENSP00000260126 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | solute carrier organic anion transporter family, member 5A1 | 0.489 |
| CSRNP1 | SUPT5H | ENSP00000273153 | ENSP00000404029 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...] | 0.575 |
| CSRNP1 | XYLB | ENSP00000273153 | ENSP00000207870 | cysteine-serine-rich nuclear protein 1; Binds to the consensus sequence 5’-AGAGTG-3’ and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a role in apoptosis | xylulokinase homolog (H. influenzae); Phosphorylates D-xylulose to produce D-xylulose 5- phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis | 0.432 |
| GPR171 | ARL5B | ENSP00000308479 | ENSP00000366487 | G protein-coupled receptor 171; Orphan receptor | ADP-ribosylation factor-like 5B; Binds and exchanges GTP and GDP | 0.526 |
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