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STRINGSTRING
CAAP1 CAAP1 HLA-G HLA-G KIR2DL2 KIR2DL2 YWHAE YWHAE STAC STAC SRC SRC FCHSD2 FCHSD2 UEVLD UEVLD TRIM45 TRIM45 KIAA1958 KIAA1958 SPG20 SPG20
"STAC" - SH3 and cysteine rich domain in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
STACSH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction (402 aa)    
Predicted Functional Partners:
HLA-G
major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells (338 aa)
            score_image   0.896
UEVLD
UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination (471 aa)
            score_image   0.823
TRIM45
tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway (580 aa)
            score_image   0.818
SPG20
spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both (666 aa)
            score_image   0.756
FCHSD2
FCH and double SH3 domains 2 (740 aa)
            score_image   0.722
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (255 aa)
        score_image       0.576
KIAA1958
KIAA1958 (716 aa)
        score_image       0.551
KIR2DL2
killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells (410 aa)
            score_image   0.538
CAAP1
caspase activity and apoptosis inhibitor 1; Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop (361 aa)
            score_image   0.533
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] (536 aa)
            score_image   0.499
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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