node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAAP1 | STAC | ENSP00000369431 | ENSP00000273183 | caspase activity and apoptosis inhibitor 1; Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop | SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction | 0.533 |
FCHSD2 | KIR2DL2 | ENSP00000386722 | ENSP00000383672 | FCH and double SH3 domains 2 | killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells | 0.535 |
FCHSD2 | SPG20 | ENSP00000386722 | ENSP00000347314 | FCH and double SH3 domains 2 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | 0.729 |
FCHSD2 | STAC | ENSP00000386722 | ENSP00000273183 | FCH and double SH3 domains 2 | SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction | 0.722 |
FCHSD2 | TRIM45 | ENSP00000386722 | ENSP00000256649 | FCH and double SH3 domains 2 | tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway | 0.815 |
FCHSD2 | UEVLD | ENSP00000386722 | ENSP00000379500 | FCH and double SH3 domains 2 | UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination | 0.757 |
HLA-G | KIR2DL2 | ENSP00000353472 | ENSP00000383672 | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells | 0.722 |
HLA-G | STAC | ENSP00000353472 | ENSP00000273183 | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction | 0.896 |
KIAA1958 | STAC | ENSP00000336940 | ENSP00000273183 | KIAA1958 | SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction | 0.551 |
KIR2DL2 | FCHSD2 | ENSP00000383672 | ENSP00000386722 | killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells | FCH and double SH3 domains 2 | 0.535 |
KIR2DL2 | HLA-G | ENSP00000383672 | ENSP00000353472 | killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells | major histocompatibility complex, class I, G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells | 0.722 |
KIR2DL2 | SPG20 | ENSP00000383672 | ENSP00000347314 | killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | 0.580 |
KIR2DL2 | STAC | ENSP00000383672 | ENSP00000273183 | killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells | SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction | 0.538 |
KIR2DL2 | TRIM45 | ENSP00000383672 | ENSP00000256649 | killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells | tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway | 0.634 |
KIR2DL2 | UEVLD | ENSP00000383672 | ENSP00000379500 | killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells | UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination | 0.630 |
SPG20 | FCHSD2 | ENSP00000347314 | ENSP00000386722 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | FCH and double SH3 domains 2 | 0.729 |
SPG20 | KIR2DL2 | ENSP00000347314 | ENSP00000383672 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1; Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells | 0.580 |
SPG20 | STAC | ENSP00000347314 | ENSP00000273183 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | SH3 and cysteine rich domain; Probably involved in a neuron-specific signal transduction | 0.756 |
SPG20 | TRIM45 | ENSP00000347314 | ENSP00000256649 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | tripartite motif containing 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway | 0.870 |
SPG20 | UEVLD | ENSP00000347314 | ENSP00000379500 | spastic paraplegia 20 (Troyer syndrome); May be implicated in endosomal trafficking, or microtubule dynamics, or both | UEV and lactate/malate dehyrogenase domains; Possible negative regulator of polyubiquitination | 0.816 |