node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD10 | ALAS1 | ENSP00000273359 | ENSP00000309259 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | aminolevulinate, delta-, synthase 1 | 0.601 |
ABHD10 | ALAS2 | ENSP00000273359 | ENSP00000332369 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | aminolevulinate, delta-, synthase 2 | 0.601 |
ABHD10 | CCDC135 | ENSP00000273359 | ENSP00000353942 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | coiled-coil domain containing 135; Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly during meiosis and spermiogenesis. May be involved in sperm motility (By similarity) | 0.520 |
ABHD10 | GCAT | ENSP00000273359 | ENSP00000371110 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | glycine C-acetyltransferase | 0.601 |
ABHD10 | MYCBPAP | ENSP00000273359 | ENSP00000323184 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | MYCBP associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.540 |
ABHD10 | OXCT2 | ENSP00000273359 | ENSP00000361914 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | 3-oxoacid CoA transferase 2; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.513 |
ABHD10 | SPTLC1 | ENSP00000273359 | ENSP00000262554 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | serine palmitoyltransferase, long chain base subunit 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isoz [...] | 0.601 |
ABHD10 | SPTLC2 | ENSP00000273359 | ENSP00000216484 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate | 0.601 |
ABHD10 | SPTLC3 | ENSP00000273359 | ENSP00000381968 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.601 |
ABHD10 | UBC | ENSP00000273359 | ENSP00000344818 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | ubiquitin C | 0.644 |
ALAS1 | ABHD10 | ENSP00000309259 | ENSP00000273359 | aminolevulinate, delta-, synthase 1 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | 0.601 |
ALAS1 | ALAS2 | ENSP00000309259 | ENSP00000332369 | aminolevulinate, delta-, synthase 1 | aminolevulinate, delta-, synthase 2 | 0.807 |
ALAS1 | GCAT | ENSP00000309259 | ENSP00000371110 | aminolevulinate, delta-, synthase 1 | glycine C-acetyltransferase | 0.912 |
ALAS1 | UBC | ENSP00000309259 | ENSP00000344818 | aminolevulinate, delta-, synthase 1 | ubiquitin C | 0.820 |
ALAS2 | ABHD10 | ENSP00000332369 | ENSP00000273359 | aminolevulinate, delta-, synthase 2 | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | 0.601 |
ALAS2 | ALAS1 | ENSP00000332369 | ENSP00000309259 | aminolevulinate, delta-, synthase 2 | aminolevulinate, delta-, synthase 1 | 0.807 |
ALAS2 | GCAT | ENSP00000332369 | ENSP00000371110 | aminolevulinate, delta-, synthase 2 | glycine C-acetyltransferase | 0.909 |
CCDC135 | ABHD10 | ENSP00000353942 | ENSP00000273359 | coiled-coil domain containing 135; Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly during meiosis and spermiogenesis. May be involved in sperm motility (By similarity) | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | 0.520 |
CCDC135 | MYCBPAP | ENSP00000353942 | ENSP00000323184 | coiled-coil domain containing 135; Plays a role in the regulation of germ cells differentiation during spermatogenesis, particularly during meiosis and spermiogenesis. May be involved in sperm motility (By similarity) | MYCBP associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) | 0.537 |
GCAT | ABHD10 | ENSP00000371110 | ENSP00000273359 | glycine C-acetyltransferase | abhydrolase domain containing 10; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate | 0.601 |