AMT protein (Homo sapiens) - STRING network view

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AMT

aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) (403 aa)

Predicted Functional Partners:

GLDC

0.999

GCSH

0.999

DLD

0.990

SHMT2

0.988

SHMT1

0.985

MTHFD2L

0.985

MTHFD2

0.984

MTHFD1L

0.983

MTHFD1

0.981

ATIC

0.941

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMT	ATIC	ENSP00000273588	ENSP00000236959	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	0.941
AMT	DLD	ENSP00000273588	ENSP00000205402	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction	0.990
AMT	GCSH	ENSP00000273588	ENSP00000319531	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.999
AMT	GLDC	ENSP00000273588	ENSP00000370737	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.999
AMT	MTHFD1	ENSP00000273588	ENSP00000450560	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.981
AMT	MTHFD1L	ENSP00000273588	ENSP00000356290	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	0.983
AMT	MTHFD2	ENSP00000273588	ENSP00000377617	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.984
AMT	MTHFD2L	ENSP00000273588	ENSP00000379108	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	0.985
AMT	SHMT1	ENSP00000273588	ENSP00000318868	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.985
AMT	SHMT2	ENSP00000273588	ENSP00000333667	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.988
ATIC	AMT	ENSP00000236959	ENSP00000273588	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	0.941
ATIC	GLDC	ENSP00000236959	ENSP00000370737	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.619
ATIC	MTHFD1	ENSP00000236959	ENSP00000450560	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	0.989
ATIC	MTHFD1L	ENSP00000236959	ENSP00000356290	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity)	0.887
ATIC	MTHFD2	ENSP00000236959	ENSP00000377617	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.960
ATIC	MTHFD2L	ENSP00000236959	ENSP00000379108	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	0.961
ATIC	SHMT1	ENSP00000236959	ENSP00000318868	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.989
ATIC	SHMT2	ENSP00000236959	ENSP00000333667	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.990
DLD	AMT	ENSP00000205402	ENSP00000273588	dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	0.990
DLD	GCSH	ENSP00000205402	ENSP00000319531	dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.901

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