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SPTLC3 SPTLC3 SPTLC1 SPTLC1 SPTLC2 SPTLC2 GINS3 GINS3 PFAS PFAS ABHD14A ABHD14A GCAT GCAT BZW2 BZW2 ALAS2 ALAS2 ALAS1 ALAS1 ZIC1 ZIC1
"ABHD14A" - abhydrolase domain containing 14A in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
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textmining
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protein homology
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[Homology]
Score
ABHD14Aabhydrolase domain containing 14A; Possible role in granule neuron development (By similarity) (271 aa)    
Predicted Functional Partners:
ZIC1
Zic family member 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Bin [...] (447 aa)
            score_image   0.861
ALAS2
aminolevulinate, delta-, synthase 2 (587 aa)
score_image       score_image   score_image   0.616
SPTLC3
serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference (552 aa)
score_image       score_image   score_image   0.601
GCAT
glycine C-acetyltransferase (445 aa)
score_image       score_image   score_image   0.601
ALAS1
aminolevulinate, delta-, synthase 1 (640 aa)
score_image       score_image   score_image   0.601
SPTLC1
serine palmitoyltransferase, long chain base subunit 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isoz [...] (473 aa)
score_image       score_image   score_image   0.601
SPTLC2
serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (562 aa)
score_image       score_image   score_image   0.601
PFAS
phosphoribosylformylglycinamidine synthase (1338 aa)
        score_image   score_image   0.551
BZW2
basic leucine zipper and W2 domains 2; May be involved in neuronal differentiation (By similarity) (419 aa)
        score_image   score_image   0.544
GINS3
GINS complex subunit 3 (Psf3 homolog); The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA (255 aa)
        score_image       0.538
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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