TRMT10A protein (Homo sapiens) - STRING network view

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TRMT10A

tRNA methyltransferase 10 homolog A (S. cerevisiae); Probable RNA methyltransferase (By similarity) (339 aa)

Predicted Functional Partners:

WDR4

0.991

METTL1

0.935

TRMT1

0.821

TRMT5

0.777

NGDN

0.660

ABT1

0.649

TRMT1L

0.620

TRMT6

0.610

PRKACA

0.538

ARPC1A

0.538

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABT1	METTL1	ENSP00000274849	ENSP00000314441	activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity)	methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	0.471
ABT1	NGDN	ENSP00000274849	ENSP00000386134	activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity)	neuroguidin, EIF4E binding protein; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity)	0.898
ABT1	TRMT1	ENSP00000274849	ENSP00000350352	activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity)	tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	0.478
ABT1	TRMT10A	ENSP00000274849	ENSP00000273962	activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity)	tRNA methyltransferase 10 homolog A (S. cerevisiae); Probable RNA methyltransferase (By similarity)	0.649
ABT1	TRMT1L	ENSP00000274849	ENSP00000356476	activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity)	tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity)	0.478
ABT1	TRMT6	ENSP00000274849	ENSP00000203001	activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity)	tRNA methyltransferase 6 homolog (S. cerevisiae); Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA	0.451
ARPC1A	PRKACA	ENSP00000262942	ENSP00000309591	actin related protein 2/3 complex, subunit 1A, 41kDa; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks	protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...]	0.478
ARPC1A	TRMT10A	ENSP00000262942	ENSP00000273962	actin related protein 2/3 complex, subunit 1A, 41kDa; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks	tRNA methyltransferase 10 homolog A (S. cerevisiae); Probable RNA methyltransferase (By similarity)	0.538
METTL1	ABT1	ENSP00000314441	ENSP00000274849	methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity)	0.471
METTL1	TRMT1	ENSP00000314441	ENSP00000350352	methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	0.856
METTL1	TRMT10A	ENSP00000314441	ENSP00000273962	methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	tRNA methyltransferase 10 homolog A (S. cerevisiae); Probable RNA methyltransferase (By similarity)	0.935
METTL1	TRMT1L	ENSP00000314441	ENSP00000356476	methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity)	0.727
METTL1	TRMT5	ENSP00000314441	ENSP00000261249	methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	tRNA methyltransferase 5 homolog (S. cerevisiae); Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5’ of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding	0.558
METTL1	TRMT6	ENSP00000314441	ENSP00000203001	methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	tRNA methyltransferase 6 homolog (S. cerevisiae); Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA	0.615
METTL1	WDR4	ENSP00000314441	ENSP00000328671	methyltransferase like 1; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit	0.999
NGDN	ABT1	ENSP00000386134	ENSP00000274849	neuroguidin, EIF4E binding protein; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity)	activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes (By similarity)	0.898
NGDN	TRMT1	ENSP00000386134	ENSP00000350352	neuroguidin, EIF4E binding protein; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity)	tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	0.524
NGDN	TRMT10A	ENSP00000386134	ENSP00000273962	neuroguidin, EIF4E binding protein; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity)	tRNA methyltransferase 10 homolog A (S. cerevisiae); Probable RNA methyltransferase (By similarity)	0.660
NGDN	TRMT1L	ENSP00000386134	ENSP00000356476	neuroguidin, EIF4E binding protein; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity)	tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity)	0.522
NGDN	TRMT6	ENSP00000386134	ENSP00000203001	neuroguidin, EIF4E binding protein; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity)	tRNA methyltransferase 6 homolog (S. cerevisiae); Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in initiator methionyl-tRNA	0.541

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