node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CORO6 | TBCK | ENSP00000344562 | ENSP00000273980 | coronin 6 | TBC1 domain containing kinase | 0.422 |
MOB1A | MOB1B | ENSP00000379364 | ENSP00000310189 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | MOB kinase activator 1B; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | 0.960 |
MOB1A | TBCK | ENSP00000379364 | ENSP00000273980 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | TBC1 domain containing kinase | 0.461 |
MOB1B | MOB1A | ENSP00000310189 | ENSP00000379364 | MOB kinase activator 1B; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | 0.960 |
MOB1B | TBCK | ENSP00000310189 | ENSP00000273980 | MOB kinase activator 1B; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | TBC1 domain containing kinase | 0.461 |
MOB2 | TBCK | ENSP00000328694 | ENSP00000273980 | MOB kinase activator 2; Stimulates the autophosphorylation and kinase activity of STK38 and STK38L | TBC1 domain containing kinase | 0.461 |
NEK10 | SGK196 | ENSP00000343847 | ENSP00000331258 | NIMA-related kinase 10 | Protein kinase-like protein SgK196 | 0.623 |
NEK10 | TBCK | ENSP00000343847 | ENSP00000273980 | NIMA-related kinase 10 | TBC1 domain containing kinase | 0.463 |
SGK110 | SGK196 | ENSP00000388220 | ENSP00000331258 | putative uncharacterized serine/threonine-protein kinase SgK110 | Protein kinase-like protein SgK196 | 0.725 |
SGK110 | TBCK | ENSP00000388220 | ENSP00000273980 | putative uncharacterized serine/threonine-protein kinase SgK110 | TBC1 domain containing kinase | 0.580 |
SGK196 | NEK10 | ENSP00000331258 | ENSP00000343847 | Protein kinase-like protein SgK196 | NIMA-related kinase 10 | 0.623 |
SGK196 | SGK110 | ENSP00000331258 | ENSP00000388220 | Protein kinase-like protein SgK196 | putative uncharacterized serine/threonine-protein kinase SgK110 | 0.725 |
SGK196 | TBCK | ENSP00000331258 | ENSP00000273980 | Protein kinase-like protein SgK196 | TBC1 domain containing kinase | 0.471 |
SLC9A3R2 | TBCK | ENSP00000408005 | ENSP00000273980 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus | TBC1 domain containing kinase | 0.519 |
TBC1D3B | TBCK | ENSP00000381781 | ENSP00000273980 | TBC1 domain family, member 3B; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | TBC1 domain containing kinase | 0.434 |
TBC1D3H | TBCK | ENSP00000409195 | ENSP00000273980 | TBC1 domain family, member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | TBC1 domain containing kinase | 0.436 |
TBCK | CORO6 | ENSP00000273980 | ENSP00000344562 | TBC1 domain containing kinase | coronin 6 | 0.422 |
TBCK | MOB1A | ENSP00000273980 | ENSP00000379364 | TBC1 domain containing kinase | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | 0.461 |
TBCK | MOB1B | ENSP00000273980 | ENSP00000310189 | TBC1 domain containing kinase | MOB kinase activator 1B; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] | 0.461 |
TBCK | MOB2 | ENSP00000273980 | ENSP00000328694 | TBC1 domain containing kinase | MOB kinase activator 2; Stimulates the autophosphorylation and kinase activity of STK38 and STK38L | 0.461 |