node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANXA2 | USP53 | ENSP00000346032 | ENSP00000274030 | annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids (By similarity). It binds two calcium ions with high affinity (By similarity). May be involved in heat-stress response (By similarity) | ubiquitin specific peptidase 53; Has no peptidase activity | 0.740 |
ARG1 | USP53 | ENSP00000357066 | ENSP00000274030 | arginase, liver | ubiquitin specific peptidase 53; Has no peptidase activity | 0.741 |
CASP14 | USP53 | ENSP00000221740 | ENSP00000274030 | caspase 14, apoptosis-related cysteine peptidase; Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity) | ubiquitin specific peptidase 53; Has no peptidase activity | 0.749 |
CPNE7 | USP53 | ENSP00000268720 | ENSP00000274030 | copine VII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | ubiquitin specific peptidase 53; Has no peptidase activity | 0.742 |
DDB2 | USP53 | ENSP00000256996 | ENSP00000274030 | damage-specific DNA binding protein 2, 48kDa; Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex [...] | ubiquitin specific peptidase 53; Has no peptidase activity | 0.914 |
FLNC | USP53 | ENSP00000327145 | ENSP00000274030 | filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers | ubiquitin specific peptidase 53; Has no peptidase activity | 0.740 |
HCFC1 | USP53 | ENSP00000309555 | ENSP00000274030 | host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...] | ubiquitin specific peptidase 53; Has no peptidase activity | 0.740 |
KRT77 | USP53 | ENSP00000342710 | ENSP00000274030 | keratin 77 | ubiquitin specific peptidase 53; Has no peptidase activity | 0.740 |
PPP2R1B | USP53 | ENSP00000311344 | ENSP00000274030 | protein phosphatase 2, regulatory subunit A, beta; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit | ubiquitin specific peptidase 53; Has no peptidase activity | 0.740 |
TGM3 | USP53 | ENSP00000370867 | ENSP00000274030 | transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase); Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are furth [...] | ubiquitin specific peptidase 53; Has no peptidase activity | 0.740 |
USP53 | ANXA2 | ENSP00000274030 | ENSP00000346032 | ubiquitin specific peptidase 53; Has no peptidase activity | annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids (By similarity). It binds two calcium ions with high affinity (By similarity). May be involved in heat-stress response (By similarity) | 0.740 |
USP53 | ARG1 | ENSP00000274030 | ENSP00000357066 | ubiquitin specific peptidase 53; Has no peptidase activity | arginase, liver | 0.741 |
USP53 | CASP14 | ENSP00000274030 | ENSP00000221740 | ubiquitin specific peptidase 53; Has no peptidase activity | caspase 14, apoptosis-related cysteine peptidase; Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity) | 0.749 |
USP53 | CPNE7 | ENSP00000274030 | ENSP00000268720 | ubiquitin specific peptidase 53; Has no peptidase activity | copine VII; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity) | 0.742 |
USP53 | DDB2 | ENSP00000274030 | ENSP00000256996 | ubiquitin specific peptidase 53; Has no peptidase activity | damage-specific DNA binding protein 2, 48kDa; Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex [...] | 0.914 |
USP53 | FLNC | ENSP00000274030 | ENSP00000327145 | ubiquitin specific peptidase 53; Has no peptidase activity | filamin C, gamma; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers | 0.740 |
USP53 | HCFC1 | ENSP00000274030 | ENSP00000309555 | ubiquitin specific peptidase 53; Has no peptidase activity | host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...] | 0.740 |
USP53 | KRT77 | ENSP00000274030 | ENSP00000342710 | ubiquitin specific peptidase 53; Has no peptidase activity | keratin 77 | 0.740 |
USP53 | PPP2R1B | ENSP00000274030 | ENSP00000311344 | ubiquitin specific peptidase 53; Has no peptidase activity | protein phosphatase 2, regulatory subunit A, beta; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit | 0.740 |
USP53 | TGM3 | ENSP00000274030 | ENSP00000370867 | ubiquitin specific peptidase 53; Has no peptidase activity | transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase); Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are furth [...] | 0.740 |