node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA1 | CCNB1 | ENSP00000255465 | ENSP00000256442 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.997 |
CCNA1 | CCNB2 | ENSP00000255465 | ENSP00000288207 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.971 |
CCNA1 | CCNB3 | ENSP00000255465 | ENSP00000276014 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cyclin B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I | 0.911 |
CCNA1 | CDC14A | ENSP00000255465 | ENSP00000354916 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | CDC14 cell division cycle 14 homolog A (S. cerevisiae); Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC- FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis | 0.579 |
CCNA1 | CDC14B | ENSP00000255465 | ENSP00000364389 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | CDC14 cell division cycle 14 homolog B (S. cerevisiae); Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint- following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases | 0.570 |
CCNA1 | CDC25C | ENSP00000255465 | ENSP00000321656 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | cell division cycle 25 homolog C (S. pombe); Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity | 0.713 |
CCNA1 | PLK2 | ENSP00000255465 | ENSP00000274289 | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | polo-like kinase 2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling- required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibito [...] | 0.989 |
CCNA2 | CCNB1 | ENSP00000274026 | ENSP00000256442 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.993 |
CCNA2 | CCNB2 | ENSP00000274026 | ENSP00000288207 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.972 |
CCNA2 | CCNB3 | ENSP00000274026 | ENSP00000276014 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I | 0.913 |
CCNA2 | CDC14A | ENSP00000274026 | ENSP00000354916 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | CDC14 cell division cycle 14 homolog A (S. cerevisiae); Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC- FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis | 0.625 |
CCNA2 | CDC14B | ENSP00000274026 | ENSP00000364389 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | CDC14 cell division cycle 14 homolog B (S. cerevisiae); Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint- following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases | 0.570 |
CCNA2 | CDC25C | ENSP00000274026 | ENSP00000321656 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cell division cycle 25 homolog C (S. pombe); Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity | 0.898 |
CCNA2 | PLK2 | ENSP00000274026 | ENSP00000274289 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | polo-like kinase 2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling- required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibito [...] | 0.990 |
CCNB1 | CCNA1 | ENSP00000256442 | ENSP00000255465 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells | 0.997 |
CCNB1 | CCNA2 | ENSP00000256442 | ENSP00000274026 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | 0.993 |
CCNB1 | CCNB2 | ENSP00000256442 | ENSP00000288207 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.961 |
CCNB1 | CCNB3 | ENSP00000256442 | ENSP00000276014 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I | 0.901 |
CCNB1 | CCNF | ENSP00000256442 | ENSP00000380256 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin F; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication | 0.839 |
CCNB1 | CDC14A | ENSP00000256442 | ENSP00000354916 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | CDC14 cell division cycle 14 homolog A (S. cerevisiae); Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC- FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis | 0.909 |