node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP35 | LCK | ENSP00000385720 | ENSP00000337825 | Rho GTPase activating protein 35; Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5’- GAGAAAAGAAACTGGAGAAACTC-3’. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor | lymphocyte-specific protein tyrosine kinase | 0.551 |
ARHGAP35 | RASA1 | ENSP00000385720 | ENSP00000274376 | Rho GTPase activating protein 35; Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5’- GAGAAAAGAAACTGGAGAAACTC-3’. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor | RAS p21 protein activator (GTPase activating protein) 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1 | 0.999 |
ARHGAP35 | RRAS | ENSP00000385720 | ENSP00000246792 | Rho GTPase activating protein 35; Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5’- GAGAAAAGAAACTGGAGAAACTC-3’. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor | related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton | 0.414 |
DOK1 | DOK2 | ENSP00000233668 | ENSP00000276420 | docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 | docking protein 2, 56kDa; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity) | 0.635 |
DOK1 | EGFR | ENSP00000233668 | ENSP00000275493 | docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 | epidermal growth factor receptor | 0.531 |
DOK1 | HRAS | ENSP00000233668 | ENSP00000309845 | docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.903 |
DOK1 | LCK | ENSP00000233668 | ENSP00000337825 | docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 | lymphocyte-specific protein tyrosine kinase | 0.993 |
DOK1 | PDGFRB | ENSP00000233668 | ENSP00000261799 | docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 | platelet-derived growth factor receptor, beta polypeptide; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of n [...] | 0.933 |
DOK1 | RASA1 | ENSP00000233668 | ENSP00000274376 | docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 | RAS p21 protein activator (GTPase activating protein) 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1 | 0.999 |
DOK2 | DOK1 | ENSP00000276420 | ENSP00000233668 | docking protein 2, 56kDa; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity) | docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 | 0.635 |
DOK2 | EGFR | ENSP00000276420 | ENSP00000275493 | docking protein 2, 56kDa; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity) | epidermal growth factor receptor | 0.649 |
DOK2 | HRAS | ENSP00000276420 | ENSP00000309845 | docking protein 2, 56kDa; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity) | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.914 |
DOK2 | LCK | ENSP00000276420 | ENSP00000337825 | docking protein 2, 56kDa; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity) | lymphocyte-specific protein tyrosine kinase | 0.969 |
DOK2 | RASA1 | ENSP00000276420 | ENSP00000274376 | docking protein 2, 56kDa; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity) | RAS p21 protein activator (GTPase activating protein) 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1 | 0.994 |
EGFR | DOK1 | ENSP00000275493 | ENSP00000233668 | epidermal growth factor receptor | docking protein 1, 62kDa (downstream of tyrosine kinase 1); DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 | 0.531 |
EGFR | DOK2 | ENSP00000275493 | ENSP00000276420 | epidermal growth factor receptor | docking protein 2, 56kDa; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity) | 0.649 |
EGFR | HRAS | ENSP00000275493 | ENSP00000309845 | epidermal growth factor receptor | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.999 |
EGFR | LCK | ENSP00000275493 | ENSP00000337825 | epidermal growth factor receptor | lymphocyte-specific protein tyrosine kinase | 0.926 |
EGFR | PDGFRB | ENSP00000275493 | ENSP00000261799 | epidermal growth factor receptor | platelet-derived growth factor receptor, beta polypeptide; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of n [...] | 0.820 |
EGFR | RASA1 | ENSP00000275493 | ENSP00000274376 | epidermal growth factor receptor | RAS p21 protein activator (GTPase activating protein) 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1 | 0.996 |