CYP39A1 protein (Homo sapiens) - STRING network view

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CYP39A1

cytochrome P450, family 39, subfamily A, polypeptide 1; Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product (469 aa)

Predicted Functional Partners:

HSD3B7

0.963

CYP46A1

0.960

SQLE

0.877

CH25H

0.862

C5orf4

0.845

MSMO1

0.845

FDFT1

0.844

LSS

0.832

AGMO

0.816

SC5DL

0.816

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGMO	C5orf4	ENSP00000341662	ENSP00000320604	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	chromosome 5 open reading frame 4	0.912
AGMO	CH25H	ENSP00000341662	ENSP00000360918	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation	0.899
AGMO	CYP39A1	ENSP00000341662	ENSP00000275016	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	cytochrome P450, family 39, subfamily A, polypeptide 1; Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product	0.816
AGMO	CYP46A1	ENSP00000341662	ENSP00000261835	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	cytochrome P450, family 46, subfamily A, polypeptide 1; Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole	0.752
AGMO	FDFT1	ENSP00000341662	ENSP00000220584	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	farnesyl-diphosphate farnesyltransferase 1	0.922
AGMO	HSD3B7	ENSP00000341662	ENSP00000297679	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis	0.717
AGMO	LSS	ENSP00000341662	ENSP00000348762	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus	0.851
AGMO	MSMO1	ENSP00000341662	ENSP00000261507	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	methylsterol monooxygenase 1	0.898
AGMO	SQLE	ENSP00000341662	ENSP00000265896	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway	0.587
C5orf4	AGMO	ENSP00000320604	ENSP00000341662	chromosome 5 open reading frame 4	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	0.912
C5orf4	CH25H	ENSP00000320604	ENSP00000360918	chromosome 5 open reading frame 4	cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation	0.420
C5orf4	CYP39A1	ENSP00000320604	ENSP00000275016	chromosome 5 open reading frame 4	cytochrome P450, family 39, subfamily A, polypeptide 1; Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product	0.845
C5orf4	CYP46A1	ENSP00000320604	ENSP00000261835	chromosome 5 open reading frame 4	cytochrome P450, family 46, subfamily A, polypeptide 1; Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole	0.573
C5orf4	FDFT1	ENSP00000320604	ENSP00000220584	chromosome 5 open reading frame 4	farnesyl-diphosphate farnesyltransferase 1	0.860
C5orf4	HSD3B7	ENSP00000320604	ENSP00000297679	chromosome 5 open reading frame 4	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis	0.760
C5orf4	LSS	ENSP00000320604	ENSP00000348762	chromosome 5 open reading frame 4	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus	0.842
C5orf4	SC5DL	ENSP00000320604	ENSP00000264027	chromosome 5 open reading frame 4	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol	0.813
C5orf4	SQLE	ENSP00000320604	ENSP00000265896	chromosome 5 open reading frame 4	squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway	0.880
CH25H	AGMO	ENSP00000360918	ENSP00000341662	cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation	alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes	0.899
CH25H	C5orf4	ENSP00000360918	ENSP00000320604	cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation	chromosome 5 open reading frame 4	0.420

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