node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP3B1 | SLC2A12 | ENSP00000255194 | ENSP00000275230 | adaptor-related protein complex 3, beta 1 subunit; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required [...] | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | 0.785 |
AP3B1 | UBC | ENSP00000255194 | ENSP00000344818 | adaptor-related protein complex 3, beta 1 subunit; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required [...] | ubiquitin C | 0.893 |
AP3B2 | SLC2A12 | ENSP00000261722 | ENSP00000275230 | adaptor-related protein complex 3, beta 2 subunit; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required [...] | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | 0.688 |
AP3B2 | UBC | ENSP00000261722 | ENSP00000344818 | adaptor-related protein complex 3, beta 2 subunit; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required [...] | ubiquitin C | 0.486 |
ENSG00000251357 | SLC2A12 | ENSP00000400325 | ENSP00000275230 | Uncharacterized protein | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | 0.541 |
INS | PPP1R3C | ENSP00000250971 | ENSP00000238994 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | 0.878 |
INS | SLC2A12 | ENSP00000250971 | ENSP00000275230 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | 0.580 |
INS | SLC5A1 | ENSP00000250971 | ENSP00000266088 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | solute carrier family 5 (sodium/glucose cotransporter), member 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2-1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules | 0.582 |
P4HA3 | PPP1R3C | ENSP00000332170 | ENSP00000238994 | prolyl 4-hydroxylase, alpha polypeptide III; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | 0.609 |
P4HA3 | SLC2A12 | ENSP00000332170 | ENSP00000275230 | prolyl 4-hydroxylase, alpha polypeptide III; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | 0.646 |
PPP1R3C | INS | ENSP00000238994 | ENSP00000250971 | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.878 |
PPP1R3C | P4HA3 | ENSP00000238994 | ENSP00000332170 | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | prolyl 4-hydroxylase, alpha polypeptide III; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins | 0.609 |
PPP1R3C | SLC2A12 | ENSP00000238994 | ENSP00000275230 | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | 0.576 |
PPP1R3C | UBC | ENSP00000238994 | ENSP00000344818 | protein phosphatase 1, regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types | ubiquitin C | 0.985 |
SLC22A1 | SLC2A12 | ENSP00000355930 | ENSP00000275230 | solute carrier family 22 (organic cation transporter), member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), coca [...] | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | 0.532 |
SLC22A2 | SLC2A12 | ENSP00000355920 | ENSP00000275230 | solute carrier family 22 (organic cation transporter), member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited b [...] | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | 0.550 |
SLC2A12 | AP3B1 | ENSP00000275230 | ENSP00000255194 | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | adaptor-related protein complex 3, beta 1 subunit; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required [...] | 0.785 |
SLC2A12 | AP3B2 | ENSP00000275230 | ENSP00000261722 | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | adaptor-related protein complex 3, beta 2 subunit; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required [...] | 0.688 |
SLC2A12 | ENSG00000251357 | ENSP00000275230 | ENSP00000400325 | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | Uncharacterized protein | 0.541 |
SLC2A12 | INS | ENSP00000275230 | ENSP00000250971 | solute carrier family 2 (facilitated glucose transporter), member 12; Facilitative glucose transporter (By similarity) | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.580 |