node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | RB1 | ENSP00000363822 | ENSP00000267163 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.953 |
AR | RBAK | ENSP00000363822 | ENSP00000275423 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | 0.918 |
FBXL19 | FBXL5 | ENSP00000369666 | ENSP00000344866 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | F-box and leucine-rich repeat protein 5 | 0.900 |
FBXL19 | RBAK | ENSP00000369666 | ENSP00000275423 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | 0.501 |
FBXL5 | FBXL19 | ENSP00000344866 | ENSP00000369666 | F-box and leucine-rich repeat protein 5 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.900 |
FBXL5 | RBAK | ENSP00000344866 | ENSP00000275423 | F-box and leucine-rich repeat protein 5 | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | 0.459 |
GNA12 | RBAK | ENSP00000275364 | ENSP00000275423 | guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | 0.445 |
KDM2A | RB1 | ENSP00000432786 | ENSP00000267163 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.608 |
KDM2A | RBAK | ENSP00000432786 | ENSP00000275423 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | 0.511 |
KDM2B | RBAK | ENSP00000366271 | ENSP00000275423 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | 0.501 |
PTPN23 | RBAK | ENSP00000265562 | ENSP00000275423 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | 0.476 |
RANBP2 | RBAK | ENSP00000283195 | ENSP00000275423 | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | 0.465 |
RB1 | AR | ENSP00000267163 | ENSP00000363822 | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.953 |
RB1 | KDM2A | ENSP00000267163 | ENSP00000432786 | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.608 |
RB1 | RBAK | ENSP00000267163 | ENSP00000275423 | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | 0.631 |
RBAK | AR | ENSP00000275423 | ENSP00000363822 | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.918 |
RBAK | FBXL19 | ENSP00000275423 | ENSP00000369666 | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
RBAK | FBXL5 | ENSP00000275423 | ENSP00000344866 | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | F-box and leucine-rich repeat protein 5 | 0.459 |
RBAK | GNA12 | ENSP00000275423 | ENSP00000275364 | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems | 0.445 |
RBAK | KDM2A | ENSP00000275423 | ENSP00000432786 | RB-associated KRAB zinc finger; May repress E2F-dependent transcription. May promote AR- dependent transcription | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.511 |