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EIF4A3 EIF4A3 NOP2 NOP2 EIF4A2 EIF4A2 DDX27 DDX27 PNMA3 PNMA3 NOC3L NOC3L NOM1 NOM1 CIRH1A CIRH1A TBL3 TBL3 RBM19 RBM19 RNF32 RNF32
"NOM1" - nucleolar protein with MIF4G domain 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
NOM1nucleolar protein with MIF4G domain 1; Plays a role in targeting PPP1CA to the nucleolus (860 aa)    
Predicted Functional Partners:
EIF4A2
eukaryotic translation initiation factor 4A2; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (407 aa)
      score_image score_image   score_image   0.936
CIRH1A
cirrhosis, autosomal recessive 1A (cirhin); May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5’-GGGACTTTCC-3’ found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV (686 aa)
      score_image score_image       0.854
EIF4A3
eukaryotic translation initiation factor 4A3; ATP-dependent RNA helicase. Component of a splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction [...] (411 aa)
      score_image score_image   score_image   0.808
RNF32
ring finger protein 32; May play a role in sperm formation (362 aa)
            score_image   0.802
NOC3L
nucleolar complex associated 3 homolog (S. cerevisiae); May be required for adipogenesis (By similarity) (800 aa)
      score_image         0.788
NOP2
NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase (808 aa)
      score_image     score_image   0.777
RBM19
RNA binding motif protein 19; Plays a role in embryo pre-implantation development (By similarity) (960 aa)
      score_image     score_image   0.777
TBL3
transducin (beta)-like 3 (808 aa)
      score_image     score_image   0.754
DDX27
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (796 aa)
      score_image score_image       0.751
PNMA3
paraneoplastic Ma antigen 3 (463 aa)
            score_image   0.751
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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