| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CNTN4 | CNTNAP2 | ENSP00000380602 | ENSP00000354778 | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | 0.854 |
| CNTN4 | NLGN4X | ENSP00000380602 | ENSP00000275857 | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | neuroligin 4, X-linked; Putative neuronal cell surface protein involved in cell- cell-interactions | 0.625 |
| CNTN4 | NRXN1 | ENSP00000380602 | ENSP00000385142 | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | neurexin 1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity) | 0.492 |
| CNTN4 | PTCHD1 | ENSP00000380602 | ENSP00000368666 | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | patched domain containing 1 | 0.400 |
| CNTNAP2 | CNTN4 | ENSP00000354778 | ENSP00000380602 | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | 0.854 |
| CNTNAP2 | NLGN4X | ENSP00000354778 | ENSP00000275857 | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | neuroligin 4, X-linked; Putative neuronal cell surface protein involved in cell- cell-interactions | 0.683 |
| CNTNAP2 | PTCHD1 | ENSP00000354778 | ENSP00000368666 | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | patched domain containing 1 | 0.514 |
| CNTNAP2 | SHANK3 | ENSP00000354778 | ENSP00000442518 | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | SH3 and multiple ankyrin repeat domains 3; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction | 0.635 |
| DLG4 | DLGAP2 | ENSP00000293813 | ENSP00000400258 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | discs, large (Drosophila) homolog-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane | 0.879 |
| DLG4 | NLGN4X | ENSP00000293813 | ENSP00000275857 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | neuroligin 4, X-linked; Putative neuronal cell surface protein involved in cell- cell-interactions | 0.758 |
| DLG4 | NRXN2 | ENSP00000293813 | ENSP00000265459 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | neurexin 2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling | 0.647 |
| DLG4 | NRXN3 | ENSP00000293813 | ENSP00000338349 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | neurexin 3; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity) | 0.609 |
| DLG4 | SHANK3 | ENSP00000293813 | ENSP00000442518 | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | SH3 and multiple ankyrin repeat domains 3; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction | 0.675 |
| DLGAP2 | DLG4 | ENSP00000400258 | ENSP00000293813 | discs, large (Drosophila) homolog-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.879 |
| DLGAP2 | NLGN4X | ENSP00000400258 | ENSP00000275857 | discs, large (Drosophila) homolog-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane | neuroligin 4, X-linked; Putative neuronal cell surface protein involved in cell- cell-interactions | 0.736 |
| DLGAP2 | NRXN1 | ENSP00000400258 | ENSP00000385142 | discs, large (Drosophila) homolog-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane | neurexin 1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity) | 0.406 |
| DLGAP2 | PTCHD1 | ENSP00000400258 | ENSP00000368666 | discs, large (Drosophila) homolog-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane | patched domain containing 1 | 0.670 |
| DLGAP2 | SHANK3 | ENSP00000400258 | ENSP00000442518 | discs, large (Drosophila) homolog-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane | SH3 and multiple ankyrin repeat domains 3; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction | 0.801 |
| NLGN4X | CNTN4 | ENSP00000275857 | ENSP00000380602 | neuroligin 4, X-linked; Putative neuronal cell surface protein involved in cell- cell-interactions | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | 0.625 |
| NLGN4X | CNTNAP2 | ENSP00000275857 | ENSP00000354778 | neuroligin 4, X-linked; Putative neuronal cell surface protein involved in cell- cell-interactions | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | 0.683 |
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