| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DCTN4 | DENND2A | ENSP00000414906 | ENSP00000275884 | dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | 0.570 |
| DCTN4 | PCF11 | ENSP00000414906 | ENSP00000298281 | dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae); Component of pre-mRNA cleavage complex II | 0.635 |
| DENND2A | DCTN4 | ENSP00000275884 | ENSP00000414906 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | 0.570 |
| DENND2A | MKRN1 | ENSP00000275884 | ENSP00000255977 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | makorin ring finger protein 1 | 0.544 |
| DENND2A | PCF11 | ENSP00000275884 | ENSP00000298281 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae); Component of pre-mRNA cleavage complex II | 0.549 |
| DENND2A | RAB9B | ENSP00000275884 | ENSP00000243298 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | RAB9B, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity) | 0.575 |
| DENND2A | RBM23 | ENSP00000275884 | ENSP00000352956 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | RNA binding motif protein 23; Probable RNA-binding protein. May be involved in pre- mRNA splicing process | 0.572 |
| DENND2A | RBM39 | ENSP00000275884 | ENSP00000253363 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | RNA binding motif protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process | 0.572 |
| DENND2A | RHOBTB3 | ENSP00000275884 | ENSP00000369318 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | Rho-related BTB domain containing 3; Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 | 0.539 |
| DENND2A | SYT10 | ENSP00000275884 | ENSP00000228567 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | synaptotagmin X; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity) | 0.502 |
| DENND2A | SYT9 | ENSP00000275884 | ENSP00000324419 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | synaptotagmin IX; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis | 0.502 |
| DENND2A | TBC1D24 | ENSP00000275884 | ENSP00000293970 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | 0.619 |
| MKRN1 | DENND2A | ENSP00000255977 | ENSP00000275884 | makorin ring finger protein 1 | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | 0.544 |
| PCF11 | DCTN4 | ENSP00000298281 | ENSP00000414906 | PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae); Component of pre-mRNA cleavage complex II | dynactin 4 (p62); Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton | 0.635 |
| PCF11 | DENND2A | ENSP00000298281 | ENSP00000275884 | PCF11, cleavage and polyadenylation factor subunit, homolog (S. cerevisiae); Component of pre-mRNA cleavage complex II | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | 0.549 |
| RAB9B | DENND2A | ENSP00000243298 | ENSP00000275884 | RAB9B, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity) | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | 0.575 |
| RAB9B | RHOBTB3 | ENSP00000243298 | ENSP00000369318 | RAB9B, member RAS oncogene family; Involved in the transport of proteins between the endosomes and the trans Golgi network (By similarity) | Rho-related BTB domain containing 3; Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 | 0.763 |
| RBM23 | DENND2A | ENSP00000352956 | ENSP00000275884 | RNA binding motif protein 23; Probable RNA-binding protein. May be involved in pre- mRNA splicing process | DENN/MADD domain containing 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport | 0.572 |
| RBM23 | RBM39 | ENSP00000352956 | ENSP00000253363 | RNA binding motif protein 23; Probable RNA-binding protein. May be involved in pre- mRNA splicing process | RNA binding motif protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process | 0.712 |
| RBM23 | SYT10 | ENSP00000352956 | ENSP00000228567 | RNA binding motif protein 23; Probable RNA-binding protein. May be involved in pre- mRNA splicing process | synaptotagmin X; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity) | 0.473 |
Share
