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STRINGSTRING
YWHAZ YWHAZ CCNY CCNY MTOR MTOR NOS3 NOS3 CDK16 CDK16 JUN JUN TDRD7 TDRD7 CCNA2 CCNA2 CDK5R1 CDK5R1 CKS1 CKS1 CKS1B CKS1B
"CDK16" - cyclin-dependent kinase 16 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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protein homology
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CDK16cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at ’Ser- 336’ (in vitro) (570 aa)    
Predicted Functional Partners:
CCNY
cyclin Y (341 aa)
        score_image   score_image   0.963
MTOR
mechanistic target of rapamycin (serine/threonine kinase); Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initi [...] (2549 aa)
      score_image score_image   score_image   0.954
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35); p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII (307 aa)
        score_image   score_image   0.923
TDRD7
tudor domain containing 7 (1098 aa)
            score_image   0.899
JUN
jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (331 aa)
        score_image   score_image   0.897
NOS3
nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) (1203 aa)
            score_image   0.889
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (245 aa)
        score_image   score_image   0.878
CKS1
CDC28 protein kinase regulatory subunit 1B; CDC28 protein kinase regulatory subunit 1B, isoform CRA_b; cDNA, FLJ92030, Homo sapiens CDC28 protein kinase regulatory subunit 1B (CKS1B),mRNA ; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function (79 aa)
      score_image score_image   score_image   0.864
CKS1B
CDC28 protein kinase regulatory subunit 1B; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function (79 aa)
      score_image score_image   score_image   0.861
CCNA2
cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions (432 aa)
  score_image   score_image score_image   score_image   0.859
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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