node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMPH | BIN1 | ENSP00000348602 | ENSP00000316779 | amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton | bridging integrator 1 | 0.636 |
AMPH | BIN3 | ENSP00000348602 | ENSP00000276416 | amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | 0.651 |
BIN1 | AMPH | ENSP00000316779 | ENSP00000348602 | bridging integrator 1 | amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton | 0.636 |
BIN1 | BIN2 | ENSP00000316779 | ENSP00000267012 | bridging integrator 1 | bridging integrator 2; Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis | 0.961 |
BIN1 | BIN3 | ENSP00000316779 | ENSP00000276416 | bridging integrator 1 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | 0.742 |
BIN2 | BIN1 | ENSP00000267012 | ENSP00000316779 | bridging integrator 2; Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis | bridging integrator 1 | 0.961 |
BIN2 | BIN3 | ENSP00000267012 | ENSP00000276416 | bridging integrator 2; Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | 0.830 |
BIN3 | AMPH | ENSP00000276416 | ENSP00000348602 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton | 0.651 |
BIN3 | BIN1 | ENSP00000276416 | ENSP00000316779 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | bridging integrator 1 | 0.742 |
BIN3 | BIN2 | ENSP00000276416 | ENSP00000267012 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | bridging integrator 2; Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis | 0.830 |
BIN3 | CDK9 | ENSP00000276416 | ENSP00000362361 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytok [...] | 0.641 |
BIN3 | ETFA | ENSP00000276416 | ENSP00000452762 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | electron-transfer-flavoprotein, alpha polypeptide; The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | 0.660 |
BIN3 | HEXA | ENSP00000276416 | ENSP00000268097 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | hexosaminidase A (alpha polypeptide); Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. The form B is active against certain oligosaccharides. The form S has no measurable activity | 0.610 |
BIN3 | HHEX | ENSP00000276416 | ENSP00000282728 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | hematopoietically expressed homeobox; Recognizes the DNA sequence 5’-ATTAA-3’. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity) | 0.564 |
BIN3 | MEPCE | ENSP00000276416 | ENSP00000308546 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | methylphosphate capping enzyme; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5’-end of 7SK snRNA, leading to stabilize it | 0.758 |
BIN3 | RAC1 | ENSP00000276416 | ENSP00000348461 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.802 |
BIN3 | RAC3 | ENSP00000276416 | ENSP00000304283 | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | 0.800 |
CDK9 | BIN3 | ENSP00000362361 | ENSP00000276416 | cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytok [...] | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | 0.641 |
CDK9 | MEPCE | ENSP00000362361 | ENSP00000308546 | cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytok [...] | methylphosphate capping enzyme; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5’-end of 7SK snRNA, leading to stabilize it | 0.992 |
ETFA | BIN3 | ENSP00000452762 | ENSP00000276416 | electron-transfer-flavoprotein, alpha polypeptide; The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) | bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin | 0.660 |