node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJC5B | HSPA13 | ENSP00000276570 | ENSP00000285667 | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | heat shock protein 70kDa family, member 13; Has peptide-independent ATPase activity | 0.867 |
DNAJC5B | HSPA14 | ENSP00000276570 | ENSP00000367623 | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | heat shock 70kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity | 0.862 |
DNAJC5B | HSPA1A | ENSP00000276570 | ENSP00000364802 | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | heat shock 70kDa protein 1A | 0.935 |
DNAJC5B | HSPA1B | ENSP00000276570 | ENSP00000364801 | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | heat shock 70kDa protein 1B | 0.935 |
DNAJC5B | HSPA1L | ENSP00000276570 | ENSP00000364805 | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | heat shock 70kDa protein 1-like | 0.954 |
DNAJC5B | HSPA2 | ENSP00000276570 | ENSP00000247207 | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | heat shock 70kDa protein 2; In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage | 0.935 |
DNAJC5B | HSPA4L | ENSP00000276570 | ENSP00000296464 | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | heat shock 70kDa protein 4-like; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity) | 0.870 |
DNAJC5B | HSPA5 | ENSP00000276570 | ENSP00000324173 | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.920 |
DNAJC5B | HSPA6 | ENSP00000276570 | ENSP00000310219 | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | heat shock 70kDa protein 6 (HSP70B’); In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity) | 0.936 |
DNAJC5B | HSPA8 | ENSP00000276570 | ENSP00000227378 | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.941 |
HSPA13 | DNAJC5B | ENSP00000285667 | ENSP00000276570 | heat shock protein 70kDa family, member 13; Has peptide-independent ATPase activity | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | 0.867 |
HSPA13 | HSPA4L | ENSP00000285667 | ENSP00000296464 | heat shock protein 70kDa family, member 13; Has peptide-independent ATPase activity | heat shock 70kDa protein 4-like; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity) | 0.468 |
HSPA14 | DNAJC5B | ENSP00000367623 | ENSP00000276570 | heat shock 70kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | 0.862 |
HSPA14 | HSPA4L | ENSP00000367623 | ENSP00000296464 | heat shock 70kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity | heat shock 70kDa protein 4-like; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity) | 0.455 |
HSPA1A | DNAJC5B | ENSP00000364802 | ENSP00000276570 | heat shock 70kDa protein 1A | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | 0.935 |
HSPA1A | HSPA4L | ENSP00000364802 | ENSP00000296464 | heat shock 70kDa protein 1A | heat shock 70kDa protein 4-like; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity) | 0.550 |
HSPA1A | HSPA8 | ENSP00000364802 | ENSP00000227378 | heat shock 70kDa protein 1A | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.571 |
HSPA1B | DNAJC5B | ENSP00000364801 | ENSP00000276570 | heat shock 70kDa protein 1B | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | 0.935 |
HSPA1B | HSPA4L | ENSP00000364801 | ENSP00000296464 | heat shock 70kDa protein 1B | heat shock 70kDa protein 4-like; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity) | 0.544 |
HSPA1L | DNAJC5B | ENSP00000364805 | ENSP00000276570 | heat shock 70kDa protein 1-like | DnaJ (Hsp40) homolog, subfamily C, member 5 beta | 0.954 |