PSKH2 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PSKH2

protein serine kinase H2 (385 aa)

Predicted Functional Partners:

MOS

0.568

R3HCC1L

0.551

VRK3

0.498

PPP3R2

0.477

CHP1

0.477

TESC

0.477

CIB1

0.477

CHP2

0.477

CIB4

0.477

PPP3R1

0.477

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHP1	PSKH2	ENSP00000335632	ENSP00000276616	calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...]	protein serine kinase H2	0.477
CHP2	PSKH2	ENSP00000300113	ENSP00000276616	calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...]	protein serine kinase H2	0.477
CIB1	PSKH2	ENSP00000333873	ENSP00000276616	calcium and integrin binding 1 (calmyrin); May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle [...]	protein serine kinase H2	0.477
CIB4	PSKH2	ENSP00000288861	ENSP00000276616	calcium and integrin binding family member 4	protein serine kinase H2	0.477
MOS	PSKH2	ENSP00000310722	ENSP00000276616	v-mos Moloney murine sarcoma viral oncogene homolog	protein serine kinase H2	0.568
PPP3R1	PSKH2	ENSP00000234310	ENSP00000276616	protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity	protein serine kinase H2	0.477
PPP3R2	PSKH2	ENSP00000363939	ENSP00000276616	protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity)	protein serine kinase H2	0.477
PSKH2	CHP1	ENSP00000276616	ENSP00000335632	protein serine kinase H2	calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...]	0.477
PSKH2	CHP2	ENSP00000276616	ENSP00000300113	protein serine kinase H2	calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...]	0.477
PSKH2	CIB1	ENSP00000276616	ENSP00000333873	protein serine kinase H2	calcium and integrin binding 1 (calmyrin); May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle [...]	0.477
PSKH2	CIB4	ENSP00000276616	ENSP00000288861	protein serine kinase H2	calcium and integrin binding family member 4	0.477
PSKH2	MOS	ENSP00000276616	ENSP00000310722	protein serine kinase H2	v-mos Moloney murine sarcoma viral oncogene homolog	0.568
PSKH2	PPP3R1	ENSP00000276616	ENSP00000234310	protein serine kinase H2	protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity	0.477
PSKH2	PPP3R2	ENSP00000276616	ENSP00000363939	protein serine kinase H2	protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity)	0.477
PSKH2	R3HCC1L	ENSP00000276616	ENSP00000298999	protein serine kinase H2	R3H domain and coiled-coil containing 1-like	0.551
PSKH2	TESC	ENSP00000276616	ENSP00000334785	protein serine kinase H2	tescalcin; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calc [...]	0.477
PSKH2	VRK3	ENSP00000276616	ENSP00000324636	protein serine kinase H2	vaccinia related kinase 3; Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus (By similarity)	0.498
R3HCC1L	PSKH2	ENSP00000298999	ENSP00000276616	R3H domain and coiled-coil containing 1-like	protein serine kinase H2	0.551
TESC	PSKH2	ENSP00000334785	ENSP00000276616	tescalcin; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calc [...]	protein serine kinase H2	0.477
VRK3	PSKH2	ENSP00000324636	ENSP00000276616	vaccinia related kinase 3; Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus (By similarity)	protein serine kinase H2	0.498

Experiments

Cooccurrence

Textmining

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About