IFNK protein (Homo sapiens) - STRING network view

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IFNK

interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin (207 aa)

Predicted Functional Partners:

IFNGR2

0.855

IL13RA1

0.817

IFNGR1

0.804

IFNAR1

0.802

IL2RB

0.802

CNTFR

0.800

ENSG00000258728

0.800

IL12RB1

0.800

CSF2RA

0.800

ENSG00000249624

0.800

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNTFR	ENSG00000258728	ENSP00000242338	ENSP00000451792	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	Uncharacterized protein	0.654
CNTFR	IFNK	ENSP00000242338	ENSP00000276943	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	0.800
CSF2RA	IFNK	ENSP00000394227	ENSP00000276943	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	0.800
ENSG00000249624	IFNK	ENSP00000388223	ENSP00000276943	Uncharacterized protein	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	0.800
ENSG00000258728	CNTFR	ENSP00000451792	ENSP00000242338	Uncharacterized protein	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	0.654
ENSG00000258728	IFNK	ENSP00000451792	ENSP00000276943	Uncharacterized protein	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	0.800
IFNAR1	IFNGR1	ENSP00000270139	ENSP00000356713	interferon (alpha, beta and omega) receptor 1; Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	0.629
IFNAR1	IFNK	ENSP00000270139	ENSP00000276943	interferon (alpha, beta and omega) receptor 1; Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	0.802
IFNGR1	IFNAR1	ENSP00000356713	ENSP00000270139	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	interferon (alpha, beta and omega) receptor 1; Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves	0.629
IFNGR1	IFNGR2	ENSP00000356713	ENSP00000290219	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2	0.980
IFNGR1	IFNK	ENSP00000356713	ENSP00000276943	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	0.804
IFNGR1	IL12RB1	ENSP00000356713	ENSP00000403103	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	interleukin 12 receptor, beta 1; Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade	0.722
IFNGR2	IFNGR1	ENSP00000290219	ENSP00000356713	interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	0.980
IFNGR2	IFNK	ENSP00000290219	ENSP00000276943	interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	0.855
IFNGR2	IL12RB1	ENSP00000290219	ENSP00000403103	interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2	interleukin 12 receptor, beta 1; Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade	0.440
IFNK	CNTFR	ENSP00000276943	ENSP00000242338	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	ciliary neurotrophic factor receptor; Binds to CNTF. The alpha subunit provides the receptor specificity	0.800
IFNK	CSF2RA	ENSP00000276943	ENSP00000394227	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.800
IFNK	ENSG00000249624	ENSP00000276943	ENSP00000388223	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	Uncharacterized protein	0.800
IFNK	ENSG00000258728	ENSP00000276943	ENSP00000451792	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	Uncharacterized protein	0.800
IFNK	IFNAR1	ENSP00000276943	ENSP00000270139	interferon, kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon- stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin	interferon (alpha, beta and omega) receptor 1; Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves	0.802

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