node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP51A1 | FDFT1 | ENSP00000003100 | ENSP00000220584 | cytochrome P450, family 51, subfamily A, polypeptide 1 | farnesyl-diphosphate farnesyltransferase 1 | 0.993 |
CYP51A1 | FDPS | ENSP00000003100 | ENSP00000349078 | cytochrome P450, family 51, subfamily A, polypeptide 1 | farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate | 0.676 |
CYP51A1 | HMGCS1 | ENSP00000003100 | ENSP00000322706 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.837 |
CYP51A1 | HMGCS2 | ENSP00000003100 | ENSP00000358414 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.672 |
CYP51A1 | IDI1 | ENSP00000003100 | ENSP00000370748 | cytochrome P450, family 51, subfamily A, polypeptide 1 | isopentenyl-diphosphate delta isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.982 |
CYP51A1 | IDI2 | ENSP00000003100 | ENSP00000277517 | cytochrome P450, family 51, subfamily A, polypeptide 1 | isopentenyl-diphosphate delta isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.648 |
CYP51A1 | MVD | ENSP00000003100 | ENSP00000301012 | cytochrome P450, family 51, subfamily A, polypeptide 1 | mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes | 0.736 |
CYP51A1 | MVK | ENSP00000003100 | ENSP00000228510 | cytochrome P450, family 51, subfamily A, polypeptide 1 | mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway | 0.734 |
CYP51A1 | SQLE | ENSP00000003100 | ENSP00000265896 | cytochrome P450, family 51, subfamily A, polypeptide 1 | squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway | 0.978 |
FDFT1 | CYP51A1 | ENSP00000220584 | ENSP00000003100 | farnesyl-diphosphate farnesyltransferase 1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.993 |
FDFT1 | FDPS | ENSP00000220584 | ENSP00000349078 | farnesyl-diphosphate farnesyltransferase 1 | farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate | 0.985 |
FDFT1 | GGPS1 | ENSP00000220584 | ENSP00000282841 | farnesyl-diphosphate farnesyltransferase 1 | geranylgeranyl diphosphate synthase 1; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins | 0.945 |
FDFT1 | HMGCS1 | ENSP00000220584 | ENSP00000322706 | farnesyl-diphosphate farnesyltransferase 1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.819 |
FDFT1 | HMGCS2 | ENSP00000220584 | ENSP00000358414 | farnesyl-diphosphate farnesyltransferase 1 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.641 |
FDFT1 | IDI1 | ENSP00000220584 | ENSP00000370748 | farnesyl-diphosphate farnesyltransferase 1 | isopentenyl-diphosphate delta isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.848 |
FDFT1 | IDI2 | ENSP00000220584 | ENSP00000277517 | farnesyl-diphosphate farnesyltransferase 1 | isopentenyl-diphosphate delta isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.654 |
FDFT1 | MVD | ENSP00000220584 | ENSP00000301012 | farnesyl-diphosphate farnesyltransferase 1 | mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes | 0.733 |
FDFT1 | MVK | ENSP00000220584 | ENSP00000228510 | farnesyl-diphosphate farnesyltransferase 1 | mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway | 0.788 |
FDFT1 | SQLE | ENSP00000220584 | ENSP00000265896 | farnesyl-diphosphate farnesyltransferase 1 | squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway | 0.980 |
FDPS | CYP51A1 | ENSP00000349078 | ENSP00000003100 | farnesyl diphosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.676 |