| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CARD6 | FAM188A | ENSP00000254691 | ENSP00000277632 | caspase recruitment domain family, member 6; May be involved in apoptosis | family with sequence similarity 188, member A | 0.800 |
| COPS5 | FAM188A | ENSP00000350512 | ENSP00000277632 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | family with sequence similarity 188, member A | 0.585 |
| COPS5 | RAD23A | ENSP00000350512 | ENSP00000467024 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome | 0.439 |
| COPS5 | UBC | ENSP00000350512 | ENSP00000344818 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | ubiquitin C | 0.995 |
| CRADD | FAM188A | ENSP00000327647 | ENSP00000277632 | CASP2 and RIPK1 domain containing adaptor with death domain; Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex | family with sequence similarity 188, member A | 0.655 |
| ELP5 | FAM188A | ENSP00000346412 | ENSP00000277632 | elongator acetyltransferase complex subunit 5; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation | family with sequence similarity 188, member A | 0.692 |
| ELP5 | GHITM | ENSP00000346412 | ENSP00000361207 | elongator acetyltransferase complex subunit 5; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation | growth hormone inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c | 0.555 |
| ELP5 | TMEM45A | ENSP00000346412 | ENSP00000319009 | elongator acetyltransferase complex subunit 5; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation | transmembrane protein 45A | 0.486 |
| ELP5 | UBC | ENSP00000346412 | ENSP00000344818 | elongator acetyltransferase complex subunit 5; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation | ubiquitin C | 0.620 |
| FAM188A | CARD6 | ENSP00000277632 | ENSP00000254691 | family with sequence similarity 188, member A | caspase recruitment domain family, member 6; May be involved in apoptosis | 0.800 |
| FAM188A | COPS5 | ENSP00000277632 | ENSP00000350512 | family with sequence similarity 188, member A | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | 0.585 |
| FAM188A | CRADD | ENSP00000277632 | ENSP00000327647 | family with sequence similarity 188, member A | CASP2 and RIPK1 domain containing adaptor with death domain; Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex | 0.655 |
| FAM188A | ELP5 | ENSP00000277632 | ENSP00000346412 | family with sequence similarity 188, member A | elongator acetyltransferase complex subunit 5; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation | 0.692 |
| FAM188A | GHITM | ENSP00000277632 | ENSP00000361207 | family with sequence similarity 188, member A | growth hormone inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c | 0.795 |
| FAM188A | GKN2 | ENSP00000277632 | ENSP00000329292 | family with sequence similarity 188, member A | gastrokine 2 | 0.581 |
| FAM188A | RAD23A | ENSP00000277632 | ENSP00000467024 | family with sequence similarity 188, member A | RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome | 0.592 |
| FAM188A | TMEM45A | ENSP00000277632 | ENSP00000319009 | family with sequence similarity 188, member A | transmembrane protein 45A | 0.607 |
| FAM188A | UBC | ENSP00000277632 | ENSP00000344818 | family with sequence similarity 188, member A | ubiquitin C | 0.795 |
| FAM188A | URGCP | ENSP00000277632 | ENSP00000396918 | family with sequence similarity 188, member A | upregulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer | 0.662 |
| GHITM | ELP5 | ENSP00000361207 | ENSP00000346412 | growth hormone inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c | elongator acetyltransferase complex subunit 5; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation | 0.555 |
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