| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMOT | DLG1 | ENSP00000361027 | ENSP00000345731 | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | discs, large homolog 1 (Drosophila) | 0.740 |
| AMOT | LIN7C | ENSP00000361027 | ENSP00000278193 | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | lin-7 homolog C (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | 0.958 |
| AMOT | MPP5 | ENSP00000361027 | ENSP00000261681 | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) | 0.998 |
| AMOT | MPP7 | ENSP00000361027 | ENSP00000337907 | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact | 0.893 |
| AMOT | UBC | ENSP00000361027 | ENSP00000344818 | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | ubiquitin C | 0.961 |
| AMOT | UIMC1 | ENSP00000361027 | ENSP00000366434 | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | ubiquitin interaction motif containing 1 | 0.891 |
| CASK | DLG1 | ENSP00000367408 | ENSP00000345731 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | discs, large homolog 1 (Drosophila) | 0.969 |
| CASK | LIN7C | ENSP00000367408 | ENSP00000278193 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | lin-7 homolog C (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | 0.981 |
| CASK | SPATA2 | ENSP00000367408 | ENSP00000289431 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | spermatogenesis associated 2; May have a role in the regulation of spermatogenesis | 0.999 |
| CASK | UBC | ENSP00000367408 | ENSP00000344818 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | ubiquitin C | 0.663 |
| CASK | UIMC1 | ENSP00000367408 | ENSP00000366434 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | ubiquitin interaction motif containing 1 | 0.891 |
| DLG1 | AMOT | ENSP00000345731 | ENSP00000361027 | discs, large homolog 1 (Drosophila) | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | 0.740 |
| DLG1 | CASK | ENSP00000345731 | ENSP00000367408 | discs, large homolog 1 (Drosophila) | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.969 |
| DLG1 | LIN7C | ENSP00000345731 | ENSP00000278193 | discs, large homolog 1 (Drosophila) | lin-7 homolog C (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | 0.916 |
| DLG1 | MPP2 | ENSP00000345731 | ENSP00000269095 | discs, large homolog 1 (Drosophila) | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.687 |
| DLG1 | MPP7 | ENSP00000345731 | ENSP00000337907 | discs, large homolog 1 (Drosophila) | membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7); Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact | 0.758 |
| DLG1 | UBC | ENSP00000345731 | ENSP00000344818 | discs, large homolog 1 (Drosophila) | ubiquitin C | 0.942 |
| LIN7C | AMOT | ENSP00000278193 | ENSP00000361027 | lin-7 homolog C (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions | 0.958 |
| LIN7C | CASK | ENSP00000278193 | ENSP00000367408 | lin-7 homolog C (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.981 |
| LIN7C | DLG1 | ENSP00000278193 | ENSP00000345731 | lin-7 homolog C (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | discs, large homolog 1 (Drosophila) | 0.916 |
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