node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNBD2 | LRRC4C | ENSP00000340954 | ENSP00000278198 | cyclic nucleotide binding domain containing 2 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | 0.760 |
DFNB31 | LRRC4C | ENSP00000354623 | ENSP00000278198 | deafness, autosomal recessive 31 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | 0.858 |
DFNB31 | NTNG1 | ENSP00000354623 | ENSP00000359085 | deafness, autosomal recessive 31 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.606 |
DFNB31 | NTNG2 | ENSP00000354623 | ENSP00000376921 | deafness, autosomal recessive 31 | netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.609 |
HSP90AA1 | HSP90AB1 | ENSP00000335153 | ENSP00000325875 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.999 |
HSP90AA1 | LRRC4C | ENSP00000335153 | ENSP00000278198 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | 0.799 |
HSP90AA1 | PRKAR1A | ENSP00000335153 | ENSP00000351410 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.727 |
HSP90AA1 | PRKAR2B | ENSP00000335153 | ENSP00000265717 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.916 |
HSP90AB1 | HSP90AA1 | ENSP00000325875 | ENSP00000335153 | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.999 |
HSP90AB1 | LRRC4C | ENSP00000325875 | ENSP00000278198 | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | 0.799 |
LRRC4C | CNBD2 | ENSP00000278198 | ENSP00000340954 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | cyclic nucleotide binding domain containing 2 | 0.760 |
LRRC4C | DFNB31 | ENSP00000278198 | ENSP00000354623 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | deafness, autosomal recessive 31 | 0.858 |
LRRC4C | HSP90AA1 | ENSP00000278198 | ENSP00000335153 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.799 |
LRRC4C | HSP90AB1 | ENSP00000278198 | ENSP00000325875 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.799 |
LRRC4C | NTNG1 | ENSP00000278198 | ENSP00000359085 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.999 |
LRRC4C | NTNG2 | ENSP00000278198 | ENSP00000376921 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.915 |
LRRC4C | PRKAR1A | ENSP00000278198 | ENSP00000351410 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.760 |
LRRC4C | PRKAR1B | ENSP00000278198 | ENSP00000353415 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.760 |
LRRC4C | PRKAR2B | ENSP00000278198 | ENSP00000265717 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.760 |
LRRC4C | TADA3 | ENSP00000278198 | ENSP00000307684 | leucine rich repeat containing 4C; May promote neurite outgrowth of developing thalamic neurons | transcriptional adaptor 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | 0.818 |