node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | ALDH18A1 | ENSP00000253792 | ENSP00000360268 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | aldehyde dehydrogenase 18 family, member A1 | 0.762 |
ACLY | CAD | ENSP00000253792 | ENSP00000264705 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.867 |
ACLY | GGT6 | ENSP00000253792 | ENSP00000458307 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.499 |
ACLY | GGTLC1 | ENSP00000253792 | ENSP00000278765 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | gamma-glutamyltransferase light chain 1 | 0.499 |
ACLY | TOP2A | ENSP00000253792 | ENSP00000411532 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | topoisomerase (DNA) II alpha 170kDa | 0.645 |
ACLY | TOP2B | ENSP00000253792 | ENSP00000396704 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene | 0.645 |
ALDH18A1 | ACLY | ENSP00000360268 | ENSP00000253792 | aldehyde dehydrogenase 18 family, member A1 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.762 |
ALDH18A1 | CAD | ENSP00000360268 | ENSP00000264705 | aldehyde dehydrogenase 18 family, member A1 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.964 |
ALDH18A1 | GGT6 | ENSP00000360268 | ENSP00000458307 | aldehyde dehydrogenase 18 family, member A1 | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.493 |
ALDH18A1 | GGTLC1 | ENSP00000360268 | ENSP00000278765 | aldehyde dehydrogenase 18 family, member A1 | gamma-glutamyltransferase light chain 1 | 0.493 |
ALDH18A1 | GPHN | ENSP00000360268 | ENSP00000417901 | aldehyde dehydrogenase 18 family, member A1 | gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released | 0.483 |
ALDH18A1 | TOP2A | ENSP00000360268 | ENSP00000411532 | aldehyde dehydrogenase 18 family, member A1 | topoisomerase (DNA) II alpha 170kDa | 0.608 |
ALDH18A1 | TOP2B | ENSP00000360268 | ENSP00000396704 | aldehyde dehydrogenase 18 family, member A1 | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene | 0.608 |
BCR | GGTLC1 | ENSP00000303507 | ENSP00000278765 | breakpoint cluster region; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity | gamma-glutamyltransferase light chain 1 | 0.406 |
CAD | ACLY | ENSP00000264705 | ENSP00000253792 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.867 |
CAD | ALDH18A1 | ENSP00000264705 | ENSP00000360268 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | aldehyde dehydrogenase 18 family, member A1 | 0.964 |
CAD | GGT6 | ENSP00000264705 | ENSP00000458307 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) | 0.485 |
CAD | GGTLC1 | ENSP00000264705 | ENSP00000278765 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | gamma-glutamyltransferase light chain 1 | 0.485 |
CAD | TOP2A | ENSP00000264705 | ENSP00000411532 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | topoisomerase (DNA) II alpha 170kDa | 0.785 |
CAD | TOP2B | ENSP00000264705 | ENSP00000396704 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene | 0.786 |