node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B3GAT3 | OVOL2 | ENSP00000265471 | ENSP00000278780 | beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I); Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal- [...] | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | 0.620 |
B3GAT3 | SLC3A2 | ENSP00000265471 | ENSP00000367123 | beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I); Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal- [...] | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids [...] | 0.537 |
B3GAT3 | SNX5 | ENSP00000265471 | ENSP00000366988 | beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I); Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal- [...] | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | 0.607 |
B3GAT3 | WDR74 | ENSP00000265471 | ENSP00000278856 | beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I); Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal- [...] | WD repeat domain 74 | 0.623 |
ID2 | OVOL2 | ENSP00000234091 | ENSP00000278780 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | 0.634 |
KAT5 | OVOL2 | ENSP00000340330 | ENSP00000278780 | K(lysine) acetyltransferase 5 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | 0.591 |
OVOL2 | B3GAT3 | ENSP00000278780 | ENSP00000265471 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I); Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal- [...] | 0.620 |
OVOL2 | ID2 | ENSP00000278780 | ENSP00000234091 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression | 0.634 |
OVOL2 | KAT5 | ENSP00000278780 | ENSP00000340330 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | K(lysine) acetyltransferase 5 | 0.591 |
OVOL2 | POLR2L | ENSP00000278780 | ENSP00000324124 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the [...] | 0.619 |
OVOL2 | POLR3F | ENSP00000278780 | ENSP00000366828 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcript [...] | 0.655 |
OVOL2 | SCP2D1 | ENSP00000278780 | ENSP00000366645 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | SCP2 sterol-binding domain containing 1 | 0.506 |
OVOL2 | SEC23B | ENSP00000278780 | ENSP00000262544 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | Sec23 homolog B (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity) | 0.561 |
OVOL2 | SLC3A2 | ENSP00000278780 | ENSP00000367123 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids [...] | 0.510 |
OVOL2 | SNX5 | ENSP00000278780 | ENSP00000366988 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | sorting nexin 5; May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation | 0.622 |
OVOL2 | WDR74 | ENSP00000278780 | ENSP00000278856 | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | WD repeat domain 74 | 0.619 |
POLR2L | OVOL2 | ENSP00000324124 | ENSP00000278780 | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the [...] | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | 0.619 |
POLR2L | POLR3F | ENSP00000324124 | ENSP00000366828 | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the [...] | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcript [...] | 0.997 |
POLR2L | SEC23B | ENSP00000324124 | ENSP00000262544 | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the [...] | Sec23 homolog B (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity) | 0.588 |
POLR3F | OVOL2 | ENSP00000366828 | ENSP00000278780 | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcript [...] | ovo-like 2 (Drosophila); DNA-binding protein that binds to the 5’-G[GCT]GGGGG-3’ core sequence. Probably acts as a transcription regulator (By similarity) | 0.655 |