node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CERS4 | ELOVL2 | ENSP00000251363 | ENSP00000346693 | ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) | ELOVL fatty acid elongase 2; Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n-6) acyl-CoA | 0.575 |
CERS4 | ELOVL5 | ENSP00000251363 | ENSP00000438095 | ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) | ELOVL fatty acid elongase 5 | 0.591 |
CERS4 | FA2H | ENSP00000251363 | ENSP00000219368 | ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) | fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids | 0.624 |
CERS4 | FADS3 | ENSP00000251363 | ENSP00000278829 | ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) | fatty acid desaturase 3 | 0.527 |
CERS4 | SPTLC2 | ENSP00000251363 | ENSP00000216484 | ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) | serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate | 0.749 |
CERS4 | SPTLC3 | ENSP00000251363 | ENSP00000381968 | ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) | serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.801 |
ELOVL2 | CERS4 | ENSP00000346693 | ENSP00000251363 | ELOVL fatty acid elongase 2; Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n-6) acyl-CoA | ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) | 0.575 |
ELOVL2 | ELOVL5 | ENSP00000346693 | ENSP00000438095 | ELOVL fatty acid elongase 2; Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n-6) acyl-CoA | ELOVL fatty acid elongase 5 | 0.902 |
ELOVL2 | FADS3 | ENSP00000346693 | ENSP00000278829 | ELOVL fatty acid elongase 2; Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n-6) acyl-CoA | fatty acid desaturase 3 | 0.771 |
ELOVL2 | FLAD1 | ENSP00000346693 | ENSP00000292180 | ELOVL fatty acid elongase 2; Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n-6) acyl-CoA | FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae); Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme | 0.664 |
ELOVL2 | SCD | ENSP00000346693 | ENSP00000359380 | ELOVL fatty acid elongase 2; Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n-6) acyl-CoA | stearoyl-CoA desaturase (delta-9-desaturase) | 0.685 |
ELOVL2 | SCD5 | ENSP00000346693 | ENSP00000316329 | ELOVL fatty acid elongase 2; Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n-6) acyl-CoA | stearoyl-CoA desaturase 5; Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position | 0.522 |
ELOVL2 | SPTLC3 | ENSP00000346693 | ENSP00000381968 | ELOVL fatty acid elongase 2; Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n-6) acyl-CoA | serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.553 |
ELOVL5 | CERS4 | ENSP00000438095 | ENSP00000251363 | ELOVL fatty acid elongase 5 | ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity) | 0.591 |
ELOVL5 | ELOVL2 | ENSP00000438095 | ENSP00000346693 | ELOVL fatty acid elongase 5 | ELOVL fatty acid elongase 2; Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20-4(n-6) acyl-CoA | 0.902 |
ELOVL5 | FADS3 | ENSP00000438095 | ENSP00000278829 | ELOVL fatty acid elongase 5 | fatty acid desaturase 3 | 0.776 |
ELOVL5 | FLAD1 | ENSP00000438095 | ENSP00000292180 | ELOVL fatty acid elongase 5 | FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae); Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme | 0.688 |
ELOVL5 | SCD | ENSP00000438095 | ENSP00000359380 | ELOVL fatty acid elongase 5 | stearoyl-CoA desaturase (delta-9-desaturase) | 0.771 |
ELOVL5 | SCD5 | ENSP00000438095 | ENSP00000316329 | ELOVL fatty acid elongase 5 | stearoyl-CoA desaturase 5; Fatty acid delta-9-desaturase that introduces a double bond in fatty acyl-coenzyme A at the delta-9 position | 0.605 |
ELOVL5 | SPTLC3 | ENSP00000438095 | ENSP00000381968 | ELOVL fatty acid elongase 5 | serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.553 |